静脉化疗联合经皮穿刺无水酒精肝内注射治疗晚期肝转移癌

Intravenous chemotherapy combined with percutaneous ethanol injection in the treatment of advanced liver metastasis of cancer

目的观察静脉化疗联合经皮穿刺无水酒精肝转移瘤内注射治疗肝转移癌的疗效。方法根据原发恶性肿瘤的来源采用不同的静脉化疗的同时,对21例肝转移瘤灶在B超引导下行瘤体内注射无水酒精治疗。结果14例有原发病灶者的原发病灶的疗效,7例为PR,无1例CR和PD;肝内转移灶经PEI治疗,每个病灶最少2次,最多8次,无水酒精用量平均为6 ml;均达到治疗有效。毒副反应为食欲低下、恶心呕吐,白细胞减少,肝功能一过性异常和穿刺部位疼痛。结论无水酒精局部注射治疗和静脉全身化疗的结合对恶性肿瘤伴肝转移的治疗可能有一定疗效,有待进一步研究和随访。

Objective To observe the intravenous chemotherapy combined with pereutaneous ethanol injection （PEI） in the treatment of metastatic tumors in the liver metastasis of cancer. Methods Specific intravenous chemotherapy was conducted according to the source of primary malignant tumors while 21 patients with liver metastatic tumors were treated with PEI under ultrasound-guide. Results 14 cases had effect for the primary focus. Seven cases were of PR and none of CR and PD. Liver metastasis was treated by PEI for each lesion at least 2 times, up to eight times, with average amount of anhydrous alcohol of 6 ml ; All patients were effectively improved. Toxieities were reflected by lower appetite, nausea, vomiting, neutropenia, transient liver function abnormalities and the puncture site pain. Conclusion Ethanol injection combined by intravenous chemotherapy in the treatment of liver metastasis of cancer may have some effect. It is up to further study and follow-up.