猪生物医学模型研究进展

Progress on Swine Biomedical Model

猪与人不仅在体重、生理特点、器官形成和疾病的发生方面都有高度的相似性,而且二者在基因组序列和染色体结构上有很高的同源性,所以猪已被作为人类研究中最主要的哺乳动物模型。目前,小型猪已被广泛应用于皮肤烧伤、肿瘤、免疫学、心血管病、糖尿病、畸形学和产期生物学、牙科、药理学等多方面的模式研究,以及对黑色素瘤和感染性疾病的基因组学研究中。在控制猪繁殖与呼吸系统综合征发生中的一些可行的基因组学方法,将为人类相似的病毒感染性疾病研究提供重要的参考。

Because the pig is similar to human in body weight, physiology, organ development and disease progression,it has been used as a major mammalian model for human studies, such as for skin physiology, cancer, immunology, obesity, pharmacology, tooth development, heart and brain disease, and so on. For genomic applications, it is very important that the pig genome has high sequence and chromosome structure homology with humans. The review highlighted genomic studies of melanoma and infectious disease resistance, and discussed the potential for applying knowledge gained with porcine reproductive and respiratory syndrome （PRRS） for human viral infectious disease studies.