摘要
Objective:To evaluate the current approaches for multimodality therapy for stage ⅠB cervical cancer.Methods:The relevant literature has served as a source for identified high or intermediate risks and management of stage ⅠB cervical cancer.Result:The high risks include pelvic lymph node metastasis(PLNM),positive resection margin(PRM),and the involvement of parametrium(IPM).The intermediate risks include deep stromal invasion(DSI),bulky tumor size(BTS),lymphovascular space invasion(LVSI).Adeno-carcinomatous histotype is the new risk feature relevant to poor prognoses.Both radical hysterectomy plus bilateral pelvic lymph node dissection(PLND) and radical radiotherapy have proven to be equally effective.Surgery is more performed for stage ⅠB1 disease;radiotherapy or chemoradiotherapy is preferable for stage ⅠB2 disease.For patients with one high risk or two of intermediate risks,radical hysterectomy plus PLND followed by concurrent chemoradiotherapy can improve overall survival(OS) and disease-free survival(DFS).Conclusion:The management should be individualized for stage ⅠB cervical cancer.The optimized multidisciplinary therapy can benefit patients with the best cure and minimum morbidity and complications.
Objective：To evaluate the current approaches for multimodality therapy for stage ⅠB cervical cancer.Methods：The relevant literature has served as a source for identified high or intermediate risks and management of stage ⅠB cervical cancer.Result：The high risks include pelvic lymph node metastasis（PLNM）,positive resection margin（PRM）,and the involvement of parametrium（IPM）.The intermediate risks include deep stromal invasion（DSI）,bulky tumor size（BTS）,lymphovascular space invasion（LVSI）.Adeno-carcinomatous histotype is the new risk feature relevant to poor prognoses.Both radical hysterectomy plus bilateral pelvic lymph node dissection（PLND） and radical radiotherapy have proven to be equally effective.Surgery is more performed for stage ⅠB1 disease;radiotherapy or chemoradiotherapy is preferable for stage ⅠB2 disease.For patients with one high risk or two of intermediate risks,radical hysterectomy plus PLND followed by concurrent chemoradiotherapy can improve overall survival（OS） and disease-free survival（DFS）.Conclusion：The management should be individualized for stage ⅠB cervical cancer.The optimized multidisciplinary therapy can benefit patients with the best cure and minimum morbidity and complications.
出处
《现代妇产科进展》
CSCD
北大核心
2009年第4期318-320,共3页
Progress in Obstetrics and Gynecology
关键词
宫颈癌
治疗方法
风险因素
淋巴结转移
Cervix neoplasms
Surgical procedures, operative
Radiotherapy
Combined modality therapy
Risk factors
