孕妇孕期血清前S1抗原检测的临床意义

Clinical significance of detecting serum Pre S1 antigen of hepatitis B in pregnant women

目的:探讨前S1抗原在孕妇孕期乙型肝炎血清标志物检查中的价值及临床意义。方法:对11529例孕产妇血清进行乙肝两对半和前S1抗原的检测(ELISA法),如乙肝两对半中一项或以上指标阳性者再用荧光定量PCR法检测HBV-DNA含量,根据检测结果进行统计学分析。结果:880例乙肝两对半抗原阳性孕产妇组中HBeAg、前S1抗原、HBV-DNA阳性率分别为15.68%,54.43%,55.11%,HBeAg阳性率与前S1抗原、HBV-DNA阳性率有统计学意义,而前S1抗原与HBV-DNA阳性率间无统计学意义;6217例抗原阴性抗体阳性孕产妇组中可检出一定比例的前S1抗原(0.53%)和HBV-DNA(0.56%)。结论:前S1抗原作为一种反映HBV复制状态和传染性的指标优于HBeAg。孕妇孕期体检应进行乙肝两对半和前S1抗原的联合检测。

Objective：To determine the value and clinical significance of Pre S I antigen in serological patterns of hepatitis B in pregnant women. Methods：HBV markers and Pre- S1 antigen were detected in 11529 serum specimens from pregnant women with ELISA kit. and then HBV DNA was detected in all serum specimens with any positive HBV marker by PCR, statistical analysis was carried out. Results：Pre SI and HBe Ag as well as HBV DNA positive rate were 15.68% , 54.43% and 55. 11% in 880 samples with HBs Ag accordingly. There was significant difference in positive rate between HBe Ag and Pre S1 as well as HBV DNA groups, adverse Pre S1 and HBV DNA. Pre S1 and HBV DNA positive rate were 0. 53% and 0. 56% in 6217 samples with HBs Ab but HBs Ag. Conclusion：Pre SI antigen, as a new marker for replication and infectivity of HBV, has a more great significance in serological patterns of hepatitis B than HBeAg. Conbined measurement of Pre SI with HBV markers can be recommended in medical examination for pregnant women.