原发性高血压患者、脑梗死患者CD40-CD40L与血小板糖蛋白的相关性研究

Study of correlation between CD40-CD40L and platelet glycoproteins in hypertension patients and cerebral infraction patients

目的:通过测定原发性高血压患者、脑梗死患者外周血中CD40、CD40L以及血小板糖蛋白CD62P、CD63、PAC-1指标,探讨两者相关性,并为临床提供早期识别和预测的指标。方法:流式细胞术(FCM)检测CD40、CD40L以及血小板糖蛋白CD62P、CD63、PAC-1。结果:高血压患者、脑梗塞患者的CD40、CD40L表达明显增高以及血小板处于高度活化状态,并与梗死灶大小有一定的相关性,且CD40-CD40L与血小板糖蛋白呈明显正相关性。结论:高血压患者、脑梗死患者CD40、CD40L及血小板膜糖蛋白的测定,可作为高血压患者、脑梗死患者的病情监测和评价血栓前状态的一个有效指标。

Objective：To explore their correlation and supply a reference measure,we examination CD40, CD40L and platelet glycoproteins in hypertension patients and cerebral infraction patients. Methods： The expression of CD40, CD40L and CD62P, CD63, PAC -1 were measured by flow cytometry（FCM）. Results：The expression of CD40, CD40L and platelet glycoprotein were higher in hypertension and cerebral infraction patients and were associated with infraction area. There was a remarkable correlation on CD40 - CD401 and platelet glycoprotein. Conclusion ：The measurement of CD40, CD40L and platelet glycoproteins are very important for determination of clinical reference values in patient＇s condition development and early diagnosis of thrombus.