妊娠高血压综合征胎盘组织中凋亡指数(AI)和增殖指数的观察

The Observation of Apoptosis Index and Proliferation Index in Placenta of Pregnancy induced Hypertension Syndrome

目的:观察妊娠高血压综合征(妊高征)胎盘组织中的细胞凋亡现象,探讨胎盘细胞凋亡在妊高征发生发展中的作用。方法:选取妊高征患者(观察组)40例和同期正常孕妇(对照组)40例,取胎盘组用光镜、电镜及TUNEL法观察计数细胞凋亡现象。结果:观察组胎盘细胞滋养细胞、合体滋养细胞、蜕膜细胞凋亡指数分别为(11.0±3.4)%、(12.2±3.6)%、(13.0±4.3)%明显高于对照组的(3.9±1.6)%、(5.3±1.7)%、(4.0±1.9)%(t=6.764,t=6.087,t=6.745,P均<0.05);观察组胎盘细胞滋养细胞增殖指数(7.8±1.7)%明显高于对照组的(2.8±1.7)%(t=5.456,P均<0.05);蜕膜细胞增殖指数分别为(1.3±1.1)%、明显低于对照组(2.2±1.5)%(t=5.956,P<0.05)。结论:妊高征胎盘组织中细胞凋亡增多,可能在妊高征发生发展过程中有重要作用。

Objective：To investigate a possible role of apoptosis in the pathophysiologic mechanism s of PIH （pregnancy induced hypertension syndrome）,Methods：40 cases of PIH （observation group） and 40 cases of normal pregnant（control group）check the placenta group light microscopy, electron microscopy and TUNEL apoptosis observed count situation.Results：The apoptosis index in placental cytotrophoblast, syncytiotrophoblast and deeidual cells in observation group were [（ 11.0±3.46 %, （12.2±3.67%, （13.0±4.3） % ] respec- tively and was significantly higher than that control group [（3.9±1.6）%,（5.3±1.7）%, （4.0±1.9）%] （t=6,764,t=6.087,t=6.745,P all 〈0.05）;The Proliferating Index in placental cytotrophoblast, syncytiotrophoblast in observation group were（7.8±1.7）% significantly higher than that control group（2.8±1.7） %t=5.456,P〈0.051The Proliferating Index in placental decidual cells in observation group were（1.3± 1.1 ）% significantly lower than that control group（2.2±1.5 ）% （t=5.857.P〈0.05）.Conclusions：Placental apoptosis increases significantly in PIH and it may play a role in the pathophysiotogic mechanism s of this syndrome.