摘要
目的:观察妊娠高血压综合征(妊高征)胎盘组织中的细胞凋亡现象,探讨胎盘细胞凋亡在妊高征发生发展中的作用。方法:选取妊高征患者(观察组)40例和同期正常孕妇(对照组)40例,取胎盘组用光镜、电镜及TUNEL法观察计数细胞凋亡现象。结果:观察组胎盘细胞滋养细胞、合体滋养细胞、蜕膜细胞凋亡指数分别为(11.0±3.4)%、(12.2±3.6)%、(13.0±4.3)%明显高于对照组的(3.9±1.6)%、(5.3±1.7)%、(4.0±1.9)%(t=6.764,t=6.087,t=6.745,P均<0.05);观察组胎盘细胞滋养细胞增殖指数(7.8±1.7)%明显高于对照组的(2.8±1.7)%(t=5.456,P均<0.05);蜕膜细胞增殖指数分别为(1.3±1.1)%、明显低于对照组(2.2±1.5)%(t=5.956,P<0.05)。结论:妊高征胎盘组织中细胞凋亡增多,可能在妊高征发生发展过程中有重要作用。
Objective:To investigate a possible role of apoptosis in the pathophysiologic mechanism s of PIH (pregnancy induced hypertension syndrome),Methods:40 cases of PIH (observation group) and 40 cases of normal pregnant(control group)check the placenta group light microscopy, electron microscopy and TUNEL apoptosis observed count situation.Results:The apoptosis index in placental cytotrophoblast, syncytiotrophoblast and deeidual cells in observation group were [( 11.0±3.46 %, (12.2±3.67%, (13.0±4.3) % ] respec- tively and was significantly higher than that control group [(3.9±1.6)%,(5.3±1.7)%, (4.0±1.9)%] (t=6,764,t=6.087,t=6.745,P all 〈0.05);The Proliferating Index in placental cytotrophoblast, syncytiotrophoblast in observation group were(7.8±1.7)% significantly higher than that control group(2.8±1.7) %t=5.456,P〈0.051The Proliferating Index in placental decidual cells in observation group were(1.3± 1.1 )% significantly lower than that control group(2.2±1.5 )% (t=5.857.P〈0.05).Conclusions:Placental apoptosis increases significantly in PIH and it may play a role in the pathophysiotogic mechanism s of this syndrome.
出处
《中国医药导刊》
2009年第3期373-374,共2页
Chinese Journal of Medicinal Guide
关键词
妊娠高血压
凋亡指数
增殖指数
胎盘
pregnancy induced hypertension syndrome
Apoptosis indexes
Proliferating index placental