盐酸地尔硫联用辛伐他汀治疗不稳定型心绞痛临床观察

Clinical Observation of Herbesser Combined with Simvastatin in Treatment of Unstable Angina Pectoris

目的:探讨盐酸地尔硫(合贝爽)联用辛伐他汀治疗不稳定型心绞痛(UAP)的临床疗效。方法:将69例不稳定型心绞痛患者随机分为观察组(35例)和对照组(34例),对照组予以常规治疗,观察组在常规治疗的基础上予以合贝爽90mg口服,每日一次,辛伐他汀40mg,每晚睡前口服,疗程均为14d。结果:观察组主要症状和ECG改善情况明显优于对照组,观察组无1例进展为急性心肌梗死(AMI)或死亡,有效率为94.29%,对照组1例进展为AMI,有效率为70.59%,二组比较差异有统计学意义。结论:合贝爽联用辛伐他汀治疗不稳定心绞痛可有效减少心绞痛发作并改善心肌缺血,疗效好且安全可靠。

Objective： To investigate the clinical effect of herbesser combined with simvastatin on unstable angina pectoris. Methods： 69 Patients with unstable angina pectoris were randonmized to study group （n=35） and control group（n=34）. The two groups were given tradioned therapy as usual, study group were received additional herbesser （90rag was taken oral per 24h for 14 days） and swovastaffn（40mg was taken oral before sleeping for 14 days）. Results： The main symptoms and ECG were alleviated obviously in study group compared with control group. There was no infarction or death in study group.But in control group,a patient developed into acute myocardial infarction.The difference of effective rate between two groups was significant（94.29% Vs 70.59%, P〈0. 01）. Conclusions： Herbesser combined with simvastatin can relieve angina pectoris and improve the myocardial ischemic,and it is an effective and safe method.