白芍配伍桂枝的抗炎作用研究

The Anti-Inflammatory Effect of Peony Root and Ramulus Cinnamomi

目的:研究白芍与桂枝配伍前后水煎煮液的抗炎作用。方法:制备白芍和桂枝配伍前后水煎液,通过复制动物模型。采取灌胃的给药方式,用鸡蛋清致大鼠足跖肿胀实验,大鼠甲醛性足跖肿胀实验,大鼠棉球肉芽肿实验以及小鼠二甲苯致耳肿胀实验,探讨白芍与桂枝配伍前后的抗炎作用。结果:灌胃给予芍-桂配伍水煎煮液与阴性对照组比较,大鼠鸡蛋清性和甲醛性足跖肿胀率明显减小,还能明显减少大鼠肉芽肿增生,对小鼠二甲苯致耳肿胀程度也有抑制作用。结论:桂枝抗炎作用较弱,白芍和桂枝配伍后,抗炎作用比白芍、桂枝显著增强。配伍中两个药物起了协同作用。

Objective：To study the effects of Peony Root and Ramulus Cinnamomi on anti-inflammation when used separately and incombination. Methods：Two drugs were prepared from decoctions separately and incombination. An experimental rat model with inflamed paw edema was induced by hen eggs or formaldehyde. The anti-inflammatory effects were been observed on the formation of cotton ball granuloma in rats. At the end, a mouse model with ear swelling induced by xylene was established. They were used to evaluate the impact of the anti-inflammatoin in Peony Root and Ramulus Cinnamomi separately and ineombination. Results：On the basis of experiments ,The anti-inflammatory effect appeared stronger when the two drugs were used in combination, especially incomparision with the use of Ramulus Cinnamomi alone. Conclusions： The drugs combination is more effective on anti-inflammation.