双炔失碳酯联合米非司酮及米索前列醇药物流产的疗效观察

The Clinical Treatment Effects of a Combination of Anordrin and Mifepristone and Misoprostol

目的:观察双炔失碳酯联合米非司酮配伍米索前列醇终止早孕的疗效。方法:选择本院2007年8月～2008年8月要求流产的健康妇女共120例,随机分为对照组及观察组各60例,对照组仅服用米非司酮和米索前列醇,观察组加服双炔失碳酯,观察两组流产效果。结果:两组完全流产率无显著性差异(P>0.05)。孕囊平均排出时间两组无显著性差异(P>0.05)。完整蜕膜排出率观察组显著高于对照组(P<0.05)。阴道持续出血时间观察组显著短于对照组(P<0.05)。副反应发生率观察组屡著低于对照组(P<0.05)。结论:双炔失碳酯能够加强米非司酮的抗早孕作用,缩短药物流产后出血时间,双炔失碳酯联合米非司酮配伍米索前列醇对提高药物流产安全性有一定的作用。

Objective：To ohserve the clinical treatment effects of a combination of anordrin and mifepristone and misoprostol. Methods： To randomly divide 120 cases healthy gravida between 2007,8 - 2008,8 into two groups. Study groups had mifepristone and misoprostol. Control groups had anordrin in addition. To observe two groups＇therapeutic effect. Results： The comparison complete abortion rates in study groups and control groups were not statistical significance （ P 〉 0.05 ）. The average times of gestational sac discard were not statistical significance （ P 〉 0.05 ）. The complete decidua discard ratew of study groups were significantly higher than that of control groups（ P 〈0. 05 ）. The time of colporrhagia of study groups were significantly shorter than that of control groups （P 〈 0. 05 ）. Adverse effect rates of study groups were significantly lower than that of control groups（ P 〈 0.05 ）. Conclusions ： Anordrin can strengthen antiearly pregnancy activity of mifepristone, to shorten the time of colporrbagia. A combination of anordrin and mifepristone and misoprostol may enhance security of medical termination of pregnancy.