阿司匹林赖氨酸盐注射剂致眼睑和结膜严重水肿

Severe edema of eyelid and conjunctiva caused by aspirin-DL-lysine for injection

1例7岁男孩因咽痛、咳嗽、发热给予阿司匹林赖氨酸0.35g溶于5%葡萄糖100ml中静脉滴注。静脉滴注约35ml,患者出现眼睑和结膜严重水肿,睑结膜轻度充血,视物略模糊。立即停药,给予地塞米松滴眼液,冷湿敷,肌内注射异丙嗪,静脉给予10%葡萄糖酸钙及地塞米松。4h后症状完全消失。

A 7-year-old boy received an IV infusion of aspirin-DL-lysine 0. 35 g dissolved in 100 ml of glucose 5% for pharyngodynia, cough, and fever. After infusion of about 35 ml, the boy presented with severe edema of eyelid and conjunctiva, slight congestion of palpebral conjunctiva, and mild blurred vision. The infusion was stopped immediately. Dexamethasone eye drops, cold wet compress, IM promethazine, Ⅳ calcium gluconate 10% , and Ⅳ dexamethasone were given. His symptoms completely disappeared 4 hours later.