摘要
1例31岁男性患者因慢性粒细胞白血病口服甲磺酸伊马替尼400mg,1次/d。患者既往无心脏病、高血压病史。治疗前心电图和超声波检查示心功能正常。治疗第1天,患者出现心前区不适。第6天出现心律失常,三度房室传导阻滞,HR45次/min。停用甲磺酸伊马替尼,给予支持治疗,安装临时起博器,患者症状好转。
A 31-year-old man received oral imatinib mesylate 400 mg once daily for chronic granulocytic leukemia. The patient had no previous history of heart disease or hypertension. An ECG and ultrasound revealed normal cardiac function before treatment. On day 1 of therapy, he experienced precordial discomfort. On day 6, he developed arrhythmia and atrioventricular block Ⅲ, his heart rate was 45 beats/min. Imatinib mesylate was discontinued. He received supportive treatment and a temporary pacemaker. His symptoms improved.
出处
《药物不良反应杂志》
2009年第2期130-131,共2页
Adverse Drug Reactions Journal
