摘要
1例17岁女性患者因急性淋巴细胞白血病口服他克莫司早2mg、晚3mg,合用的药物有法莫替丁注射液、米卡芬净注射液、阿奇霉素氯化钠注射液。治疗30d后,患者出现睡眠时间延长、少言、反应慢等症状,并逐渐发展为嗜睡、记忆力减退、幻视、语速缓慢、计算错误等。考虑该神经系统不良反应可能是和他克莫司与阿齐霉素联用有关。停用他克莫司,2d后患者症状减轻。
A 17-year-old girl was treated with oral tacrolimus 2 mg in the morning and 3 mg in the evening for acute lymphocytic leukemia; the combined drugs included famotidine injection, micafungin injection, and azithromycin sodium chloride injection. After 30 days of treatment, the patient developed prolonged sleeping time, reduced speech, and slowed responses, and then progressed gradually to lethargy, decreased memory, visual hallucination, slowed speech, and incorrect calculation, and so on. The neurological disorder was considered to be possibly tacrolimus plus azithromycin-assoeiated. Tacrolimus was discontinued. Two days later, his symptoms relieved.
出处
《药物不良反应杂志》
2009年第2期137-138,共2页
Adverse Drug Reactions Journal
关键词
他克莫司
认知障碍
不良反应
tacrolimus
cognitive impairment
adverse reactions
