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非格司亭引起造血干细胞健康供者频繁呕吐

Frequent vomiting occurring in a normal hematopoietic stem cell donor receiving filgrastim
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摘要 1例34岁女性造血干细胞健康供者,为动员骨髓干细胞皮下注射非格司亭300μg,2次/d。第2天供者出现头痛、腰痛、恶心、呕吐症状。第3天症状加重,呕吐频繁(每日4~5次),不能进食。血常规检查示:WBC66×109/L,PLT221×109/L,Hb124g/L。4d以后逐渐好转。 A 34-year-old woman, who was a normal hematopoietic stem cell donor, received SC filgrastim 300 μg twice daily for mobilization of bone marrow stem cell. The next day, the donor experienced headache, lumbago, nausea, and vomiting. On day 3, her symptoms became aggravated, her vomiting was frequent (4 to 5 times daily) and led to eating difficulties. Routine blood tests revealed a WBC count of 66 ×10^9/L, a PLT count of 221×10^9/L, and a Hb level of 124 g/L. She gradually improved 4 days later.
机构地区 解放军第
出处 《药物不良反应杂志》 2009年第2期141-141,共1页 Adverse Drug Reactions Journal
关键词 非格司亭 频繁呕吐 不良反应 filgrastim frequent vomiting adverse reactions
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参考文献1

  • 1Cavallaro AM, Lilleby K, Majolino I, et al. Three to six year follow-up of normal donors who received recombinant human granulocyte colony-stimulating factor [ J]. Bone Marrow Transplant, 2000, 25 ( 1 ) : 85-89.

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