原因不明发热97例病因分析

Cause analysis of 97 cases with fever of unknown origin

目的探讨不明原因长期发热的病因。方法回顾性地分析总结1997年1月至2007年10月间在我院住院且符合不明原因长期发热诊断标准的97例患者的临床资料，对其确诊情况及病因进行分析与比较。结果97例患者经各种检查或试验性治疗最后明确诊断者有82例，确诊率为84．5％。82例确诊的患者病因包括：感染性疾病45例，占46．4％，细菌性感染42例占感染性疾病的93．3％，其中结核病、布氏杆菌病和伤寒／副伤寒各占细菌性感染的21．4％（9／42）、14．3％（6／42）和14．3％（6／42）；结缔组织病16例，占16．5％；肿瘤性疾病13例，占13．4％；其他疾病8例，占8．2％；原因仍未明者15例，占15．5％。结论感染性疾病仍然是不明原因长期发热的主要病因，结核病、布氏杆菌病和伤寒／副伤寒也是感染性疾病中的主要病种；结缔组织病和肿瘤性疾病也占有相当比例；大多数发热通过仔细检查和分析最终可明确诊断。

Objective To investigate the cause of fever of unknown origin （FUO）. Methods Clinical data of 97 patients with FUO from January 1997 to December 2007 were analyzed. Results After various examinations and specific treatment,the definite diagnosis was finally made in 82 cases. 45 cases （46.4%） were caused by infections, among them 93.3% was due to bacterium, 21.4% by tuberculosis, 14.3% by brucellosis and 14.3% by typhiod/paratyphoid. 16 cases （16.5%） were caused by connective tissue diseases; 13 cases （13.4%） were tumors; 8 cases （8.2%） were other diseases. 15 cases （ 15.5% ） was of unknown causes. Conclusion Infection is the main cause of FUO. Connective tissue diseases and tumors are also the common causes of FUO.