自然周期IVF-ET248例临床分析

Clinical analysis of 248 cases with natural cycle IVF-ET

目的:探讨自然周期体外受精-胚胎移植(NC-IVF-ET)技术在不孕症治疗中的临床应用价值。方法:采用SPSS统计软件包对248例行NC-IVF-ET和2185例行控制性超排卵(短方案COH)助孕的患者促排卵结果进行分析。结果:NC-IVF-ET组的获卵率和临床妊娠率显著低于COH组(P<0.05),周期取消率显著高于COH组(P<0.05),但两组正常受精率、卵裂率和种植率均无显著性差异(P>0.05)。而NC-IVF-ET组的OHSS发生率和多胎妊娠率则显著低于COH组(P<0.05)。在各种原因引起的不孕症中,输卵管因素引起的不孕症临床妊娠率最高,而无获卵是最主要的取消原因。结论:NC-IVF-ET不使用促排卵药物,经济、安全,应在有适应证的不孕症患者中加以应用。

Objective： To investigate the clinical value of natural cycle in vitro fertilization and embryo transfer （NC-IVF-ET） in the treatment of infertility. Methods： SPSS statistic software was used to analyze the clinical results of 248 patients received the treatment of the protocol of NC-IVF-ET and 2 185 patients received the treatment of controlled ovarian hyperstimulation （short protocol COH）. Results： The rate of oocytes retrieved and the rate of clinical pregnancy of NC-IVF-ET group were significantly lower than that of COH group （P〈0.05）, and the cycle cancellation rate was significantly higher than that of COH group （P〈0.05）, but the normal rate of fertilization, mcrogenesis rate and planting rate showed no difference between the two groups （P〉0.05）. The rate of OSS and the multifetal pregnancy in NC-IVF-ET group were significantly lower than that of COH group （P〈0.05）. The rate of clinical pregnancy of the infertile couples which caused by ovarian duct obstruction was the highest, and no retrieved oocyte was the main reason of cycle cancelling. Conclusion： The protocol of NC-IVF-ET has the advantages of no need of ovarian stimulation medicine and is more economic and safe, it should be used in some patients who have indications.