口服伊曲康唑与氟康唑治疗念珠性阴道炎疗效比较

Evaluating the efficacy of the treatments for beaded vaginitis between oral itraconazole and fluconazole

目的:评价伊曲康唑与氟康唑治疗念珠性阴道炎疗效。方法:采用单盲法随机分组,将129例念珠菌患者分为两组。伊曲康唑组65例,伊曲康唑200mg/d,口服,连服3d;氟康唑组64例,氟康唑150mg/d,口服,连服3d。结果:两组患者的指标无显著性差异,资料具有可比性,伊曲康唑组与氟康唑组治疗后的总有效率分别为95%(62/65)和94%(60/64),两组比较无显著性差异(P>0.05)。不良反应发生情况为伊曲康唑组3例(5%),氟康唑组2例(3%),主要为胃肠道反应。结论:伊曲康唑与氟康唑治疗念珠性阴道炎的疗效、不良反应无显著性差异(P>0.05)。临床疗效确切,使用安全、方便。

Objective： To evaluate the efficacy of treatment for beaded vaginitis between itraconazole and fluconazole. Methods： The single-blind way with randomized groups was taken. 129 patients were divided into two groups： the itraconazole group, 65 cases, with 200 mg oral for 3 days. the fluconazole group, 64 cases, with 150 mg oral for 3 days. Results： there was no statistically significant difference between the indicators of two groups. The data was comp arable. The effective rates in itraconazole group and fluconazole group were respectively 95 percent （62/65） and 94 percent （60/64） （P〉0.05）. The incident rate of adverse reactions in itraconazole group was 5 percent （3 cases） and in fluconazole group was 3 percent （2 cases）, mainly gastrointestinal reactions. Conclusion： There is no significant difference （P〉0.05） in effectiveness and bad reactions in the treatments for beaded vaginltis bewteen itraconazole and flueonazole. The clinical effectiveness is definite, salt and convenient.