国产吉西他滨联合5-氟尿嘧啶治疗晚期胰腺癌临床观察

Domestic gemcitabine and 5 fluorouracil treatment for advanced pancreatic cancer

目的:观察国产吉西他滨联合5-氟尿嘧啶治疗晚期胰腺癌临床疗效及不良反应。方法:19例晚期胰腺癌患者随机分为两组,观察组10例,给予GCF方案(吉西他滨联合5-氟尿嘧啶),21天为1周期;对照组9例,给予FAM方案(5-氟尿嘧啶联合阿霉素、丝裂霉素),21天为1周期,均至少化疗2周期。结果:19例患者均可评价疗效和不良反应。临床受益反应率明显优于对照组(50%vs22%,P<0.05);观察组中位生存期和1年生存率也明显优于对照组(P<0.05);主要不良反应为白细胞下降、胃肠道反应,均较对照组轻,其它不良反应两组相似均可耐受。结论:吉西他滨联合5-氟尿嘧啶治疗晚期胰腺癌近期临床疗效较高,不良反应可以耐受。

Objective：To observe the effect of domestic gemcitabine and 5 -fluorouracil treatment for advanced pancreatic cancer. Methods：Nineteen patients with advanced pancreatic cancer patients were randomly divided into two groups, the observer group 10 cases treated with GCF programme （gemcitabine and 5 -fluorouracil）, a cycle of 21 days for the control group nine cases, given FAM programme （5 -fluorouracil combined doxorubicin, silk out Adriamycin） ,for a period of 21 days,at least two cycles. Results：All 19 patients can be evaluated. Clinical benefit response rate was superior to the control group （50% vs 22% P 〈0.05） ;observer group in the median survival time and one - year survival rate was significantly better than the control group （ P 〈 0.05 ） ; major adverse reactions were leukopenia, stomach reaction,light than the control group, other adverse reactions can be tolerated. Conclusion：Gemcitabine and 5 - fluorouracil treatment for advanced pancreatic cancer is effective the recent high, adverse reactions can be tolerated.