FSH在上皮性卵巢肿瘤中的表达及意义

Expression and significance of FSH in epithelium ovarian tumor

目的:研究卵泡刺激素(FSH)在良性、交界性、恶性上皮性卵巢肿瘤的表达。方法:放射免疫法对62例上皮性卵巢癌、30例交界性上皮性卵巢肿瘤及51例良性上皮性卵巢肿瘤患者血清及卵巢肿瘤组织液中的FSH进行测定。结果:FSH在卵巢癌患者血清和肿瘤组织液的表达(32.86mIU/ml,23.04mIU/ml)存在显著差异(P<0.05);在交界性上皮性卵巢肿瘤患者血清和肿瘤组织液的表达(36.29mIU/ml,29.12mIU/ml)存在显著差异(P<0.05);在良性上皮性卵巢肿瘤患者血清和肿瘤组织液的浓度表达(20.97mIU/ml,4.96mIU/ml)存在显著差异(P<0.01),在良性与恶性之间、良性与交界性之间FSH浓度均存在显著差异,且随着恶性程度的增高,FSH的浓度也呈增高趋势;而在交界性、恶性上皮性肿瘤组织液和血清中的浓度表达无明显统计学意义(P>0.05);I-II期与III-IV期卵巢癌患者血清和肿瘤组织液FSH表达无明显统计学意义(P>0.05)。结论:卵巢肿瘤组织中FSH表达升高可能与卵巢癌的发生有一定的关系。

Objective：To study the expression of follicleslimuiating hormone （FSH） in ovarian tumor. Methods： We measured the concentration of FSH in serum and tissue fluid of ovarian tumor. Results：There was a significant difference about concentration of FSH （36.29mIU/ml, 29. 12 mlU/ml） between serum and tissue fluid of ovarian cancer （ P 〈 0.05 ）, and that （ 32.86mIU/m1,23.04 mIU/ml） between serum and tissue fluid of borderline tumor（ P 〈 0.05 ）, and that （20.97mIU/m1,4.96 mIU/ml ） between serum and tissue fluid of benign tumor（ P 〈 0.01 ）. There was also significant difference between malignant and benign tumor. FSH in malignat and borderline tumors was high- er than the others,while there was no significant difference about concentration of FSH between borderline tumor and benign tumor（ P 〉 0. 05 ） and betweenⅠ - Ⅱ stage and Ⅲ- Ⅳ stage of ovarian cancer（ P 〉 0.05 ）. Conclusion ： High expression of FSH may be related with ovarian carcinogenesis.