可调控输液器在晚期顽固性癌痛中的应用

Clinical application of adjustable solution administration set in advanced refractory cancer pain

目的:评价应用可调控输液器持续静脉滴注吗啡治疗晚期顽固性癌痛的疗效及可行性。方法:应用可调控输液器持续静脉滴注吗啡治疗晚期顽固性癌痛患者18例,观察治疗前后的疼痛程度、生活质量和不良反应。结果:18例患者持续静脉滴注吗啡前后疼痛评分分别为8.72±1.21和2.72±1.54(P<0.05);其中完全缓解(CR)4例(22.2%),部分缓解(PR)9例(50.0%),轻度缓解(MR)5例(27.8%)。疼痛缓解率(CR+PR)为72.2%。疼痛开始明显缓解时间为0.5-2小时,平均1.2小时。不良反应主要为恶心、呕吐、便秘、嗜睡和轻度呼吸抑制。所有患者经治疗后生活质量明显提高。结论:应用可调控输液器持续静脉滴注吗啡能有效缓解晚期顽固性癌痛,提高患者生活质量,是一种安全、经济、简单、易行的方法。

Objective：To evaluate the efficacy and feasibility of morphine continuous intravenous infusion through adjustable solution administration set in treatment of the patients with advanced refractory cancer pain. Methods： Eighteen patients with advanced refractory cancer pain were enrolled. The morphine continuous intravenous infusion method was used to observe the effect and side effects. Results ： The pain scores of the patients before and after morphine infusion were 8.72 ± 1.21 and 2.72 ± 1.54 respectively （ P 〈 0.05）. The complete remission （CR） was 4 cases （ 22.2 % ） , partial remission （PR） 9 cases （ 50.0% ） , mild remission （MR） 5 cases （ 27.8 % ）. The pain relief rate （ CR ＋ PR） was 72.2%. The average time of remarkable pain relief was 1.2 hour. The main side effects included nausea, vomiting, constipation, lethargy and mild short breath. The quality of life was improved significantly. Conclusion：The morphine continuous intravenous infusion through adjustable solution administration set is a safe method which can relieve the advanced refractory cancer pain significantly and improve the quality of life is a simple, cheap and feasible method.