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2型糖尿病中葡萄糖代谢异常的研究进展 被引量：6

Progresse Studying of the Disorder of Glucose Metabolism in Type 2 Diabetes
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摘要 葡萄糖代谢异常是2型糖尿病的主要病理生理改变,胰岛素依赖性和非胰岛素依赖性葡萄糖代谢通路的多个环节发生了异常改变,阐明2型糖尿病葡萄糖代谢异常的分子机制,对糖尿病的治疗和预防具有重大意义。 Abnormality of glucose metabolism is the majority physiology and pathology disorder of type 2 diabetes, and many pathways in insulin dependent or insulin independent glucose metabolism became unconventional. It has great importance in prevention and therapy of diabetes to illustrate the mechanism of the disorder of glucose metabolism in type 2 diabetes.
作者 侯志敏
机构地区 廊坊师范学院
出处 《廊坊师范学院学报（自然科学版）》 2009年第2期59-61,共3页 Journal of Langfang Normal University(Natural Science Edition)
关键词 2型糖尿病 葡萄糖代谢 胰岛素抵抗 type 2 diabetes glucose metabolism insulin resistance
分类号 Q455 [生物学—生理学]
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参考文献20

  • 1Gastaldelli A et al.Influence of obesity and type 2 diabetes on gluconeogenesis and glucose output in humans:A quantitative study[J].Diabetes,2000,49:1367-1373.
  • 2Del Prato S et al.Basal plasma insulin levels exert a qualitative but not quantitative effect on glucose-mediated glucose uptake[J].Am J Physiol,1995,268:E1089-E1095.
  • 3Gastaldelli A et al.Effect of physiological hyperinsulinemia on gluconeogenesis in nondiabetic subjects and in type 2 diabetic patients.Diabetes,2001,50:1807-1812.
  • 4Clore JN et al.Ghcose-6-phosphatase flux in vitro is increased in type 2 diabetes[J].Diabetes,2000,49:969 -974.
  • 5Caro JF et al.Liver glucokinase:Decreased activity in patients with type Ⅱ diabetes[J].Horm Metab Res,1995,27:19-22.
  • 6Meyer C et al.Abnormal renal and hepatic glucose metabolism in type 2 diabetes mellitus[J].J Clin Invest,1998,102:619-624.
  • 7Bonadonna RC et al.Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM[J].Diabetes,1996,45:915-925.
  • 8Cline G W et al.Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type2 diabetes[J].N Engl J Med,1999,341:240-246.
  • 9Garvey W T et al.Evidence for defects in the trafficking and translocation of GLUT4 glucose transporters in skeletal muscle as a cause of human insulin resistance[J].J Clin Invest,1998,101:2377-2386.
  • 10Pendergrass M et al.Insulin-induced hexokinase Ⅱ expression is reduced in obesity and NIDDM[J].Diabetes,1998,47:387-394.

同被引文献74

  • 1张玲芝,冯磊.灵芝多糖降血糖的机理探讨[J].福建医药杂志,2004,26(3):137-140. 被引量：28
  • 2杨天德,杨宗城,罗奇志.烟雾吸入伤大鼠肺组织抗氧化酶活性和谷胱甘肽含量变化[J].重庆医学,2004,33(11):1625-1626. 被引量：4
  • 3叶牡丹,陈冀杭.运动对衰老机体抗氧化能力影响综述[J].武汉体育学院学报,2005,39(6):66-68. 被引量：4
  • 4周吉银,周世文.链脲菌素和四氧嘧啶诱导糖尿病大鼠模型的比较[J].江西中医学院学报,2006,18(4):44-46. 被引量：15
  • 5Suwa M, Nakano H, Radak Z, et al. Effects of Nitric Oxide Synthase Inhibition on Fiber-Type Composition, Mito- chondrial Biogenesis, and SIRT 1 Expression in Rat Skeletal Muscle[J] .J Sports Sei Med,2015,14(3) :548 - 555.
  • 6Tengan C H,Rodrigues G S, Godinho R O. Nitric oxide in skeletal muscle: role on mitochondrial biogenesis and func- tion[J]. Int J Mol Sei, 2012,13(12):17160- 17184.
  • 7Toledo JJ, Augusto O. Connecting the chemical and biologi- cal properties of nitric oxide[J]. Chem Res Toxieol, 2012, 25(5) :975 - 989.
  • 8Dudzinski DM, Igarashi J, Greif D, et al. The regulation and pharmacology of endothelial nitric oxide synthase[ J].Annu Rev Pharmacol T oxicol, 2006, (46):235- 276.
  • 9Eghbalzadeh K, Brixius K, Bloch W,et al. Skeletal muscle nitric oxide (NO) synthases and NO-signaling in "diabe- sity" what about the relevance of exercise training in- terventions? [J]. Nitric Oxide,2014, (37) :28 - 40.
  • 10Lira VA, Brown DL, Lira AK, et al. Nitric oxide and AMPK cooperatively regulate PGC - 1 in skeletal muscle ceils[ J]. J Physiol, 2010,588(18) : 3551 - 3566.

引证文献6

二级引证文献52

廊坊师范学院学报（自然科学版）
2009年 第2期

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