珠海香洲区体检人群静脉血细胞分析参考值调查

Investigation of blood cell reference level within healthy crowd in Zhuhai area

目的探讨珠海香洲区健康体检人群静脉血细胞参考值水平。方法采用回顾分析的方法,随机抽取973例例行健康体检人员,用ABXPENTRA60全自动血细胞分析仪进行血液细胞学22项参数分析,并与原参考值不同性别、不同地区进行比较,观察血细胞参考值的变化。结果珠海香洲区健康体检人群90%(20/22)的血细胞参考值与以往沿用的参考值发生了明显的改变,其中红细胞(WBC)、白细胞(RBC)、血红蛋白(Hb)、血小板(PLT)、嗜酸性粒细胞比率(EO%)、嗜碱性粒细胞比率(BASO%)、中性粒细胞(NEUT)、淋巴细胞(LYMPH)、EO、BASO、红细胞比容(HCT)、红细胞体积分布宽度(RDW-SD)现调查值比原参考值偏低,而NEUT(%)、MONO(%)、LYMPH(%)、单核细胞比率(MONO)、平均红细胞体积(MCV)、平均红细胞血红蛋白量(MCH)、RDW-CV、RDW、血小板体积分布宽度(PDW)、MPV、P-LCR现调查值比原参考值偏高,WBC、RBC、Hb、PLT、NEUT(%)、MONO(%)、EO(%)、BASO(%)、NEUT、MONO、LYMPH、EO、BASO、MCV、RDW-CV、血小板压积(PCT)、PDW、血小板平均体积(MPV)与原参考值比较,差异有统计学意义(P<0.1);RBC、Hb、HCT、MCHC、RDW、NEUT(%)、EO(%)、BASO(%)、NEUT、EO男性高于女性,MONO(%)男性低于女性,男女之间的差异有统计学意义(P<0.01),血小板4项参数PLT,PDW,MPV,P-LCR男女之间差异无统计学意义(P>0.05)。珠海地区与包头市、贵阳市、广州市所报道的血细胞参考值范围亦不同,77.27%(17/22)的血细胞参数与包头市结果间差异具有统计学意义,92.3%(12/13)与贵阳市结果间差异具有统计学意义,78.5%(11/14)与广州市结果间差异亦具有统计学意义(P<0.01)。结论珠海地区健康体检人群血细胞参考值范围与原参考值发生了改变,原参考值已不能很好地适用于临床和健康体检的需要,有必要科学、合理地建立地区性的血细胞参考值范围。

Objective To research blood cell reference level of healthy crowd in Zhuhai Xianzhou district. Methods Retroopective analysis method was adopted,and 973 cases were selected from the crowd for routine health check,and the changes about the reference value of blood cell were observed by using ABX PENTRA 60 automated hematology analyzer to analyze 26 parameters of blood cytology and comparing with the original values in different sex and different areas. Results 90 % （20/22） of blood cell reference value of healthy crowd in Zhuhai was obviously different from reference value used before： WBC, RBC, Hb, PLT, EO （ % ）, BASO（ % ）, NEUT, LYMPH, EO, BASO, HCT and RDW-SD, which was lower than the original value. WBC, RBC, Hb, PLT, NEUT（%）, MONO（G）, EO （ % ） BASO（ % ）, NEUT, MONO, LYMPH, EO, BASO, MCV, RDW-CV, RDW-SD, PDW, MPV and P-LCR had significant differnce（P〈0.01）. RBC, Hb, HCT,MCHC,RDW-CV,NEUT（%） ,EO（%） ,BASO（%） ,NEUT and Eo of men were higher than those of women,MONO（%）of men was lower than that of women. Value of men and women had significant differences（P〈0.01）. Four parameters PLT,PDW, MPV,P-LCR of blood platelet had no signifieant difference（P〈0.05）. The blood cell referenee value was different among Zhuhai,Baotou[77.27%（17/22）],Guiyang [92.3%（12/13）] and Guangzhou[78. 5% （11/14）]（P〈0.01）. Conclusion Blood cell referenee value of healthy people in Zhuhai is different from the original reference value, so the original reference value can not meet the needs of medical and health and it is necessary to build the seientifie and rational regional blood eell reference range.