血清淀粉样蛋白A与2型糖尿病及其合并大血管病变的关系

Relationship between serum levels of high-sensitivity serum amyloid A and pathogenesis of macrovascular complication in type 2 diabetes mellitus

目的探讨血清淀粉样蛋白A(serumamyloid A,SAA)与2型糖尿病及其合并大血管病变患者的关系。方法将65例2型糖尿病患者按一定的纳入标准分成不伴血管病变34例和合并大血管病变组31例,另抽取30名健康体检者作为健康对照组。在特种蛋白仪上采用比浊法测定血清SAA水平,并进行分析。结果2型糖尿病组SAA水平显著高于健康对照组,差异具有统计学意义P<0.05),并发大血管病变患者SAA与不伴大血管病变患者组比较差异也具有统计学意义(P<0.05)。结论SAA在2型糖尿病及并发大血管病变患者中明显升高,在其发生发展中具有重要的临床意义,可能是2型糖尿病大血管病变的重要的危险因素。

Objective To investigate the serum amyloid A（SAA） concentrations in type 2 diabetes mellitus （T2DM） and its macrovascular complications, to study the relation between SAA and diabetes mellitus. Methods The serum SAA level was determined by ELISA in 65 T2DM patients（31 cases with macrovascular complications and 34 cases withont macrovascular complication） and 30 healthy controls. Results Serum SAA level were significantly elevated in the patients with T2DM as compared with control subjects（P〈0.05）. There was significant difference of SAA level between T2DM patients with and without macrovascular complication（P〈0.05）. Conclusion In the patients with T2DM, serum SAA concentration is greater than in non-diabetic subjects. SAA plays an important role in the initiation and development of T2DM. The study suggestes that SAA might be important independent risk factor.