期刊文献+

原发性肝癌发病的分子机制研究进展 被引量:1

原文传递
导出
摘要 原发性肝癌(primary hepatocellular carcinoma,HCC)是指肝细胞或肝内胆管细胞发生的癌,是恶性程度及转移率很高的肿瘤之一。近年来,随着分子生物学技术的不断进步,对HCC发病机制的研究愈发深入。
出处 《医学新知》 CAS 2009年第2期109-112,117,共5页 New Medicine
  • 相关文献

参考文献3

二级参考文献18

共引文献52

同被引文献14

  • 1Lee JJ,Von Kessler DP,Parks S,et al.Secretion and locaized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog[J].Cell,1992,71(1):33-50.
  • 2Ingham PW,McMahon AP.Hedgehog signaling in animal development:Paradigms and principles[J].Genes Dev,2001,15(23):3059-3087.
  • 3Zhu SL,Luo MQ,Peng WX,et al.Sonic hedgehog signalling pathway regulates apoptosis through Smo protein in human umbilical vein endothelial cells[J].Rheumatology(Oxford),2014,17:421.
  • 4Zheng X,Yao Y,Xu Q,et al.Evaluation of gliomaassociated oncogene 1 expression and its correlation with the expression of sonic hedgehog,E-cadherin and S100a4in human hepatocellular carcinoma[J].Molecular Medicine Reports,2010,3(6):965-970.
  • 5Sicklick JK,Li YX,Jayaraman A,et al.Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis[J].Carcinogenesis,2006,27(4):748-757.
  • 6Xiao H,Cheng S,Tong R,et al.BAG3regulates epithelial-mesenchymal transition and angiogenesis in human hepatocellular carcinoma[J].Lab Invest,2014,94(3):252-261.
  • 7Von Hoff D D,LoRusso P M,Rudin C M,et al.Inhibition of the hedgehog pathway in advanced basal-cell carcinoma[J].New England Journal of Medicine,2009,361(12):1164-1172.
  • 8Tremblay M R,Lescarbeau A,Grogan M J,et al.Discovery of a potent and orally active hedgehog pathway antagonist(IPI-926)[J].Journal of medicinal chemistry,2009,52(14):4400-4418.
  • 9Taipale J,Chen J K,Cooper M K,et al.Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopa mine[J].Nature,2000,406(6799):1005-1009.
  • 10Rudin CM,Von Hoff DD,LoRusso PM,et al.Updated safety and efficacy data from a first-in-human,first-in-class phase I study of Hedgehog pathway antagonist GDC-0449[J].Eur J Cancer,2008,6:112-112.

引证文献1

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部