药物治疗非酒精性脂肪性肝病进展

Treatment strategy of nonalcoholic fatty liver disease.

非酒精性脂肪性肝病(NAFLD)是发达国家引起肝功能异常最常见的原因,治疗的重点在于阻止疾病的进展,去除引起代谢综合征的危险因素,如肥胖、胰岛素抵抗及血脂紊乱等。随着NAFLD的发病机制逐渐揭示,可选择的治疗方法除减肥外,药物治疗有抗氧化剂、胰岛素增敏剂、降脂药和肝脏保护剂。本文重点对药物治疗的进展做一综述。

Nonalcoholic fatty liver disease （ NAFLD ） is the most common cause for elevated liver enzymes in the developed nations. The treatment should be focused on the most important risk factors, obesity and insulin resistance. As a consequence of elucidating the pathogenesis of NAFLD, the number of potential therapeutic options increased, including weight reduction,antioxidants,insulinsensitizer,lipid lowering drugs and other liver protective drugs. The drug therapy for NAFLD was reviewed in this paper.