复方贞术调脂胶囊对大鼠非酒精性脂肪肝的影响

The influence of compound Zhenzhu Tiaozhi capsules on nonalcoholic fatty liver disease(NAFLD) in rats

目的探讨复方贞术调脂胶囊对大鼠非酒精性脂肪肝的影响,为其临床用药提供依据。方法取SD大鼠60只,随机分成正常组、模型组、复方贞术调脂胶囊高、中、低组、非诺贝特组。除正常组外,其他组采用高脂乳剂灌胃复制大鼠非酒精性脂肪肝模型,造模同时复方贞术调脂胶囊高、中、低组、非诺贝特组连续给药8周后,测定肝脏胆固醇(TC)、三酰甘油(TG),并计算肝指数,光镜下观察肝脏病理学变化。结果复方贞术调脂胶囊能降低肝脏TC和肝指数。肝脏病理切片结果显示复方贞术调脂胶囊组肝细胞脂肪变性、水样变性及坏死和炎症细胞浸润等病理表现均有所减轻,明显轻于模型组。结论复方贞术调脂胶囊对非酒精性脂肪肝有较好的防治作用。

Objective To study the effects of compound Zhenzhu Tiaozhi capsules on nonalcoholic fatty liver disease （NAFLD） in rats. Methods 60 SD Rats were randomly divided into 6 groups： normal group, model group, compound Zhenzhu Tiaozhi capsules high dose group, moderate dose group, low dose group, and the fenofibrate group. Rats model with nonalcoholic fatty liver disease were established with administration of high fat emulsion by gavage. The rats in the treatment groups were administered with test drugs. After 8 weeks, liver cholesterol （ TC ）, triglyeride （TG） were determined and liver index was calculated. Pathological changes in liver were observed by light microscopy. Results The liver TC and liver index of the rats administered with compound Zhenzhu Tiaozhi capsules were significantly reduced, and pathological changes were significantly ameliorated in the rats administered wit compound Zhenzhu Tiaozhi capsules. Conclusions Compound Zhenzhu Tiaozhi capsules has better therapeutic effects on nonalcoholic fatty liver disease in rats.