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磷酸化Akt和caspase-3在鼻咽癌中的表达及意义

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作者 刘敏 王朝晖 陈英杰
机构地区 大连医科大学附属第二医院实验中心 中国医科大学病理教研室
出处 《中国老年学杂志》 CAS CSCD 北大核心 2009年第8期1033-1034,共2页 Chinese Journal of Gerontology
关键词 鼻咽癌 磷酸化AKT CASPASE-3 增殖
分类号 R739.65 [医药卫生—肿瘤] R730.261 [医药卫生—肿瘤]
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参考文献8

  • 1Sarbassov DD,Guertin DA,Ali SM,et al.Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex[J].Science,2005;307(5712):1098-101.
  • 2Persad S,Attwell S,Gray V,et al.Regulation of protein kinase B/Akt-serine 473 phosphorylation by integrin-linked kinase:critical roles for kinase activity and amino acids arginine 211 and serne343[J].J Biol Chem,2001;276(29):27462-9.
  • 3Reif S,Lang A,Lindquist JN,et al.The role of focal adhesion kinase-phosphatidylinositol 3-kinase-Akt signaling in hepatic stellate cell proliferation and type Ⅰcollagen expression[J].J Biol Chem,2003;278(10):8083-90.
  • 4Jetzt A,Howe JA,Horn MT,et al.Adenoviral-mediated expression of a kinase-dead mutant of Akt induces apoptosis selectively in tumor cells and suppresses tumor growth in mice[J].Cancer Res,2003;63(20):6697-706.
  • 5West KA,Brognard J,Clark AS,et al.Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells[J].J Clin Invest,2003;111(1):81-90.
  • 6夏曙,于世英.抑制PI3K/Akt信号转导通路提高化疗效果的实验研究[J].肿瘤,2006,26(4):311-313. 被引量：21
  • 7Brognard J,Clark AS,Ni Y,et al.Akt/protein kinase B is constitutively active in non-small cell cancer cells and promotes cellular survival and resistance to chemotherapy and radiation[J].Cancer Res,2001;61(10):3986-97.
  • 8Puduvalli VK,Sampath D,Bruner JM,et al.TRAL-induced apoptosis in gliomas is enhanced by Akt-inhibition and is independent of JNK activation[J].Apoptosis,2005;10(1):233-43.

二级参考文献5

  • 1WEST K A, CASTILLO S S, DENNIS P A. Activation of the P13K/Akt pathway and chemotherapeutic resistance[J]. Drug Resist Updat ,2002,5(6) :234-248.
  • 2BONDAR V M, SWEENEY-GOTSCH B, ANDREEFF M, et al. Inhibition of the phosphatidylinositol 3'-kinase-AKT path way induces apoptosis in pancreatic carcinoma cells in vitro and in vivo [J]. Mol Cancer Ther, 2002,1 (12):989-997.
  • 3KIM MS,PARK MJ,MOON EJ,etal. Hyaluronicacid induces osteopontin via the phosphatidylinositol 3-kinase/Akt pathway to enhance the motility of human glioma cells[J].Cancer Res, 2005,65(3) :686-691.
  • 4CLARK AS,WEST K,STREICHER S,et al. Constitutive and inducible ANT activity promotes resistance to chemotherapy,trastuzumab, or tamoxifen in breast cancer cells[J]. Mol Cancer Ther, 2002,1 (9) : 707-717.
  • 5SAKUNTALA WG,JULIE L, ELISABETH B,et al. The insulin-llke growth faetor-I receptor kinase inhibitor, NVPADW742, sensitizes small cell lung cancer cell lines to the effects of chemotherapy [J]. Clin Cancer Res, 2005,11 (15):1563-1571.

共引文献20

中国老年学杂志
2009年 第8期

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