降糖复方对亚急性衰老模型小鼠的抗氧化作用

Anti-oxidative effect of Jiangtang compound recipe on subacute aging model mice

目的:研究由葛根、鱼腥草、鬼箭羽三味中药组成的复方对D-半乳糖诱导的衰老模型小鼠的抗氧化作用。方法:采用D-半乳糖诱导小鼠衰老模型,以其体重变化、血清与组织中丙二醛(MDA)含量、超氧化物歧化酶(SOD)与谷胱甘肽过氧物酶(GSH-Px)活力为指标,考察药物对衰老小鼠的抗氧化作用。结果:降糖复方(14、7g/kg,i.g.)能对抗D-半乳糖所致衰老模型小鼠血清与组织中MDA含量的升高,提高其中SOD与GSH-Px活力,并能抑制小鼠体重的下降。结论:降糖复方能有效地对抗D-半乳糖所致小鼠的氧化损伤,具有一定的抗氧化作用。

AIM： To study the effect of antioxidation in subacute aging model mice with Jiangtang compound recipe which composed of kudzuvine root, heartleaf houttuynia herb and Evonymus alatas. METHODS： By using the D-galactose-induced aging mice, the body weight, the content of malondialdehyde （MDA）, the activities of superoxide dismutarse （SOD） and glutothine peroxidase（GSH-Px） in serum and tis- sues were determined. RESULTS：To the model mice, Jiangtang compound recipe （14, 7 g/kg, i.g. ） reduced the content of MDA, enhanced the activities of SOD and GSH-Px in serum and tissuses, inhibited the decrease of body weight. CONCLUSION： Jiangtang compound recipe shows a remarkable anti-oxidative ef- fect on the D-galactose-induced aging mice.