高游离脂肪酸血症所致胰岛素抵抗与氧化应激的关系

Relationship between insulin resistance and oxidative stress caused by elevated concentration of free fatty acids

研究高游离脂肪酸（FFA）血症所致大鼠机体氧化应激及胰岛素抵抗之间的相互关系，以及其对机体抗氧化能力的影响，探讨胰岛素抵抗的病理生理机制。经研究证实大鼠高FFA血症不仅使组织活性氧簇生成增加[（886±105vs427±42）mmol／L，P〈0．05]，同时损伤机体抗氧化能力，细胞内还原型谷胱甘肽生成减少[（272±47vs561±36）μmol／L，P〈0．05]，导致氧化应激，从而促进胰岛素抵抗的形成。

The relationship between elevated concentration of circulating free fatty acids （FFA） and insulin resistance was studied, and the pathophysiological mechanism of insulin resistance, especially focused on oxidative stress, was explored. It was found that the elevated circulating FFA level led to insulin resistance in rats, which was partly caused by oxidative stress, and that antioxidative treatment was able to reverse the pathologic change. As a result of enhancing reactive oxygen species production [ （ 886 ± 105 vs 427 ±42 ） mmol/L, P〈0.05 ] and disrupting antioxidant [ （272 ±47 vs 561±36 ） μmol/L, P〈0.05 ], elevated concentration of FFA may induce oxidative stress.