期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

长期高脂饲养大鼠骨骼肌musclin表达上调及其与胰岛素抵抗的相关性 被引量：2

Mnsclin gene overexpression in skeletal muscle of rats with long-term high-fat diet and its correlation with insulin resistance
原文传递
导出
摘要 研究高脂饮食状态下Wistar大鼠骨骼肌中musclin基因表达及其与胰岛素抵抗以及糖尿病、葡萄糖转运蛋白4（GLUT-4）等的关系，结果提示musciin的表达增加（1．39±0．36vs0．31±0．07，P〈0．01）可能与胰岛素抵抗有关，有可能是胰岛素抵抗、糖尿病的一个前期信号，其作用可能与GLUT-4（1．27±0．32vs1．84±0．24，P〈0．01）有一定的关系。 The expression of musclin gene in skeletal muscle of rats fed with high-fat diet and its correlation to insulin resistance, diabetes mellitus and GLUT-4 were explored. The results showed that musclin expressin was up-regulated （ 1.39±0.36 vs 0. 31±0.07 ,P〈0. 01 ） in skeletal muscle of rats fed with high-fat diet, suggesting that this finding may be related with insulin resistance and involvement of GLUT-4 expression （ 1.27 ±0.32 vs 1.84±0.24 ,P〈0.01 ）.
作者 曹玲玲 袁莉 徐江祥 刘志强 王霞 张贝 邱海燕 徐国玲 唐兆生
机构地区 九江市第一人民医院干部病房 华中科技大学附属协和医院内分泌科
出处 《中华内分泌代谢杂志》 CAS CSCD 北大核心 2009年第2期208-209,共2页 Chinese Journal of Endocrinology and Metabolism
关键词 胰岛素抵抗 Musclin 葡萄糖转运子-4 基因表达 Insulin resistance Muselin Glucose transporter 4 Gene expression
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献8

  • 1Nishizawa H, Matsuda M, Yamada Y, et al. Muselin, a novel musclederived secretory factor. J Biol Chem,2004, 279:19391-19395.
  • 2Storlien LH, Oakes ND, Pan DA, et al. Syndrome of insulin resistance in the rats: inducement by diet and amelioration with Benflv~orex. Diabetes, 1993,42:457-462.
  • 3Kraegen EW, James DE, Bennett SP, et al. In vivo insulin sensitivity in the rat determined by euglyeemic clamp. Am J Physiol, 1983,245 : :E1 -E7.
  • 4Shimomura I, Funahashi T, Takahashi M, et al. Enhenced expression of PAI-1 in visceral fat:possible contributor to vascular disease in obesity. Nat Med, 1996,2 : 800-803.
  • 5Zisman A, Peroni OD, Abel ED, et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nat Med ,2000,6:924-928.
  • 6Norris AW, Chen L, Fisher SJ, et al. Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones. J C lin Invest, 2003,112 : 608 -618.
  • 7Bergman RN, van Citters GW, Mittelman SD, et al. Central role of the adipocyte in the metabolic syndrome. J Investig Med, 2001, 49: 119-126.
  • 8Gao Z, Zhang X, Zuberi A, et al. Inhibition of insulin sensitivity by free fatty acid requires activating of multiple serine kinase in 3TS-L1 adipocytes. Mol Endocrinol,2004,18 : 2024-2034.

同被引文献19

  • 1Yin RX,Pan SL, Chen H, et al. Diet, alcohol consumption, and serum lipid levels of the middle-aged and eldly in the Guangxi Bai Ku Yao and Han populations. Alcohol,42:219-229.
  • 2Furuya DT,Binsack R,Machado UF. Low ethanol consumption increases insulin sensitivity in Wistar rats. Biochem Biophys Res Commun,2003, 36 : 125-130.
  • 3Nguyen MT, Satoh H, Favelyukis S, et al. JNK and tumor necrosis factor-α mediate free fatty acid-induced insulin resistance in 3T3-L1 adepocytes. J Biol Chem,2005 ,280 :35361-35371.
  • 4Homes BF,Sparling DP,Olson AL,et al. Regulation of muscle GLUT4 enhancer factor and myocyte enhancer factor 2 by AMP-activated protein kinase. Am J Physiol Endocrinol Metab,2005,289 :E1071-E1076.
  • 5Nishizawa H, Matsuda M, Yamada Y, et al. Musclin, a novel skeletal muscle-derived secretory factor. J Biol Chen, 2004,279 : 19391 -19395.
  • 6Thomas G, Moffatt P, Salois P, et al. Osteocrin, a novel bone-specific secreted protein that modulates the osteoblast phenotype. J Bioi Chen, 2003,278 : 50563 - 50571.
  • 7Moffatt P, Thomas G, Sellin K, et al. Osteocrin is a specific ligand of the natriuretic peptide clearance receptor that modulates bone growth. J Bioi Chern, 2007,282 : 36454 - 36462.
  • 8Kita S,Nishizawa H, Okuno Y ,et al. Competitive binding of musclin to natriuretic peptide receptor 3 with atrial natriuretic peptide. J Endocrinol ,2009,201 : 287 - 295.
  • 9Staiger H, Haas C, Machicao F, et al. The PP AR gamma agonist troglitazone induces musclin mRNA expression in human myotubes. Horm Metab Res, 2006,38 : 614 - 616.
  • 10Sun C, Peng Y, Jiang D, et al. The potential lipolysis function of musclin and its mRNA expression both in Pig adipose tissue and primary adipocyte. Afr J Biotechnol, 2009, 8 : 6457 -6463.

引证文献2

二级引证文献2

中华内分泌代谢杂志
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部