期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

miRNA与神经系统 被引量：2

miRNA and nervous system
下载PDF
导出
摘要 microRNA(miRNA)是一类约21～25个核苷酸的非编码小RNA分子,功能复杂,主要通过碱基互补配对导致靶基因mRNA的降解或翻译抑制。miRNA具有进化保守性、组织特异性和表达时序性,从而决定组织和细胞的功能特异性。miRNA在中枢神经系统中含量丰富,在神经系统的发育及可塑性中发挥重要作用,并且与神经系统有关疾病的发生发展密切相关。 MicroRNAs （miRNAs） , an abundant class of small non-coding RNAs, have the intricate functions and mainly cause the degeneration and translational suppression of the target mRNA by base complementary pairing. Conservatism, tissue specificity and time-ordered in expression are the obvious characteristics of miRNA and by which miRNA to determine the function specificity of tissues and cells, miRNAs are abundant in the central nervous system where they play important roles in the neuronal development and plasticity. Moreover, the relationship between miRNA dysfunction and neurological diseases become more and more apparent.
作者 赵克芳 周红 凌树才
机构地区 江苏大学基础医学与医学技术学院基础医学研究所 浙江大学医学院人体解剖教研室
出处 《国际病理科学与临床杂志》 CAS 2009年第2期175-179,共5页 Journal of International Pathology and Clinical Medicine
关键词 MIRNA 神经系统 发育 miRNA nervous system development
分类号 R741 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献24

  • 1Kawaji H, Hayashizaki Y. Exploration of small RNAs [ J ]. PLoS Genet, 2008 ,4( 1 ) :e22.
  • 2Pillai RS, Bhattaeharyya SN, Filipowicz W. Repression of protein synthesis by miRNAs: how many mechanisms ? [ J ]. Trends Cell Biol, 2007, 17(3) : 118-126.
  • 3Davis TH, Cuellar TL, Koch SM, et al. Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus[ J]. J Neurosci ,2008,28 ( 17 ) :4322-4330.
  • 4Lee RC, Feinbaum RL, Ambros V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14[J]. Cell, 1993,75(5) :843-854.
  • 5Reinhart BJ, Slack FJ, Basson M, et al. The 21- nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans [J]. Nature, 2000, 403(6772) :901-906.
  • 6Yu JY, Chung KH, Deo M,et al. MicroRNA miR-124 regulates neurite outgrowth during neuronal differentiation [ J ]. Exp Cell Res, 2008,314(14) :2618-2633.
  • 7Tang G, Tang X, Mendu V, et al. The art of microRNA: various strategies leading to gene silencing via an ancient pathway [ J]. Biochim Biophys Acta, 2008,1779 ( 11 ) :655-662.
  • 8Eulalio A, Huntzinger E, Izaurralde E. Getting to the root of miRNA-mediated gene silencing[J].Cell, 2008,132( 1 ) :9-14.
  • 9杜秋丽.miRNA及其功能研究[J].生物学通报,2004,39(8):13-15. 被引量：9
  • 10Bussing I, Slack FJ, Grosshans H. let-7 microRNAs in development, stem cells and cancer[ J]. Trends Mol Med, 2005,14(9) : 400-409.

二级参考文献25

  • 1Mallory A. C., Reinhart B. J., Bartel D. et al.A viral suppressor of RNA silencing differentially regulates the accumulation of short interfering RNAs and micro-RNAs in tobacco. Proc Natl Acad Sci USA,2002,99(23): 15228- 15233.
  • 2Couzin J.. Breakthrough of The Year: Small RNAs make big splash.Science,2002,298(5602): 2296-2297.
  • 3Lim L.P.,Glasner M.E.,Yekta S. et al.Vertebrate microRNA genes.Science, 2003,299: 1540- 1546.
  • 4Lim L.P., Lau N.C.,Weinstein E.G. et al. The microRNAs of Caenorhabditis elegans. Genes Der, 2003, 17: 991-1008.
  • 5Reinhart B.J.,Weinstein E.G.,Rhoades M. W. et al. MicroRNAs in plants. Genes Dev,2002,16: 1616-1626.
  • 6Dostie L., Mourelatos Z., Yang M. et al. Numerous microRNPs in neuronal cells containing novel micro RNAs. RNA, 2003,9: 180-186.
  • 7Zeng Y., Cullen B.R.. Sequence requirements for microRNA processing and function in human cells. RNA,2003,9(1):112-123.
  • 8Ruvkun G..Molecular biology: glimpses of a tiny RNA world. Science,2001,294 (5543):797-799.
  • 9Lagos-Quintata M.,Rauhut R., Lendeckel W. et al.Identification of novel genes coding for small expressed RNAs. Science,2001, 294(5543):853-858.
  • 10Lau N.C.,Lim L.P.,Weinstein E.G.et al.An abundant class of tiny RNAs with probable regulatory roles in Caenorhabditis elegans.Science,2001,294(5543):858-862.

共引文献8

同被引文献28

引证文献2

二级引证文献6

国际病理科学与临床杂志
2009年 第2期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部