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共刺激分子4—1BB与类风湿性关节炎

The costimulatory molecule 4-1BB and rheumatoid arthritis
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摘要 共刺激分子4-1BB及其配体4-1BBL属于肿瘤坏死因子超家族成员，为、T细胞的活化、增殖提供第二信号，并可促进细胞因子的分泌。类风湿性关节炎（RA）是一种慢性系统性自身免疫性疾病，已证实T细胞功能的偏移及细胞因子表达异常在RA的免疫炎症损伤的发生发展过程中起着重要作用，而4-1BB作为RA发病机制中的关键性因素已成为目前研究的热点，通过干预4-1BB／4—1BBL信号途径对RA进行免疫治疗也已是当前的研究方向。 Costimulator molecules 4-1BB and its ligand 4-1BBL belong to the TNF super family. They provide the second signal for the activation and proliferation of T lymphocytes and increase some cytokine .production. It was discovered that disturburance of T cells and the related eytokine secretion participated in the immunopathologie process of rheumatic arthritis （ RA ） , a common chronic systemic autoimrnune disease. 4-1BB/4-1BBL＇ s dual immunoregnlative effects were currently studied in many research papers. Thus the immune internvention of the 4-1BB /4-1BBL signal is becoming a theraputie approach for various kinds of diseases. In this paper ,we discuss about their biologic and constructive effects on the pathogeneis, diagnosis and treatment of RA.
作者 闵月
机构地区 苏州大学附属儿童医院肾脏免疫科硕士研究生
出处 《国际免疫学杂志》 CAS 北大核心 2009年第3期230-234,共5页 International Journal of Immunology
基金 基金项目：国家自然科学基金资助项目（30271234） 江苏省卫生厅课题资助项目（H2005020）
关键词 4-1BB 类风湿性关节炎 共刺激分子 免疫性疾病 发病机制 4-1BB Rheumatoid arthritis
分类号 R593.22 [医药卫生—内科学] R392.11 [医药卫生—免疫学]
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参考文献20

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二级参考文献50

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国际免疫学杂志
2009年 第3期

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