树突状细胞在结核病免疫应答中的作用及机制

The mechanisms of dendritic cells in immune response to mycobacterium tuberculosis

作为最有效的专职抗原提呈细胞（DC），树突状细胞在结核病免疫中的作用日益受到关注。机体感染结核杆菌后，未成熟DC（iDC）捕获抗原并逐渐发育成熟，携带抗原成份从感染组织迁移至外周免疫器官，将抗原成份提呈给T、B淋巴细胞激发免疫应答，起着连接固有免疫和适应性免疫作用，并通过分泌IL-12、IFN-γ等细胞因子参与机体免疫调节。深入研究DC在结核病免疫中的作用机制将为抗结核新型疫苗的开发及免疫治疗方案的设计提供依据。

As the most efficient professional antigen presenting cell, dendritic cell and its role in immunity to myeobacterium tuberculosis have been caught a growing concern. After the infection of myeobacterium tuberculosis , immature dendritic cell integrates innate and adaptive immunity by capturing the microbial anti- gens, migrating from infected tissues to peripheral immune organs and presenting antigens to T, B lymphocytes. Dendritic cell secretes cytokines such as IL-12 and IFN-γ, which regulate the immune system . Study on the mechanisms of dendritic cell in immunity to mycobacterium tuberculosis provides basis for the development of novel anti-tuberculosis vaccine and immunotherapy.