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转化生长因子-β的活化机制 被引量：2

The activation pathways of transforming growth factor-β
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摘要 转化生长因子-β（TGF-β）是一类具有多种生物学效应的细胞因子。正常情况下，TGF-β以无活性的潜伏态形式合成分泌，且必须在某种机制下活化才能发挥其生物学作用。近年来研究发现，TGF-β在体内主要以两种途径活化：蛋白水解途径及非蛋白水解途径，需要多种细胞内蛋白参与，其中血小板反应素-1（TSP—1）和αv族整合素的作用尤其重要。因而进一步了解TGF-β的活化机制有利于从分子水平上开辟新的研究方向及TGF-β的生物学应用。 Transforming growth factor-β （TGF-β） is a kind of muhipotent cytokines. Normarly, TGF-β is secreted as inactive form. To exert its biological functions, it needs to be activated under certain mechanisms. Reserches have shown that TGF-β is mainly activated through two pathways in vivo： proteolysis and non-proteolysis. Many intracellular proteins are involved in the activation of TGF-β. TSP-1 and αv integrins are especially important, Further understanding the mechanisms of TGF-β activation may be beneficial to the finding of new research fields and the application of TGF-β.
作者 李晋辉
机构地区 四川大学华西第二医院儿科博士研究生
出处 《国际免疫学杂志》 CAS 北大核心 2009年第3期245-247,共3页 International Journal of Immunology
基金 基金项目：国家自然科学基金资助项目（30770748）
关键词 细胞因子 转化生长因子-Β 血小板反应素 整合素 Cytokine Transforming growth factor-β Thrombospondin Integrin
分类号 R285.5 [医药卫生—中药学]
  • 相关文献

参考文献20

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共引文献5

同被引文献23

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国际免疫学杂志
2009年 第3期

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