红霉素与阿奇霉素序贯治疗儿童支原体肺炎的临床观察

Clinical observation of erythromycin and azithromycin in sequential trealment of children mycoplasma pneumonia

目的探讨单用阿奇霉素和红霉素、阿奇霉素序贯治疗支原体肺炎的疗效、安全性和经济性。方法将116例支原体肺炎患儿随机分为两组，治疗组I采用30mg／（1（g·d）的红霉素静注，继而10mg／（kg·d）的阿奇霉素121服；治疗组Ⅱ采用10mg／（kg·d）的阿奇霉素静注，继而口服相同剂量的阿奇霉素。观察两组的临床疗效、不良反应。结果治疗组Ⅰ和治疗组Ⅱ总有效率分别为96．6％、89．7％，组间差异无统计学意义，其中治疗组Ⅰ的临床症状、体征消失时间小于治疗组Ⅱ（x^2=78．86，P〈0．05），两组治疗中不良反应的差异均无统计学意义。结论红霉素和阿奇霉素序贯治疗的疗效优于单一阿奇霉素序贯治疗，且耐受性更好，更经济。

Objective To explore the efficacy, safety and economy of azithromycin, the combination of erythromycin and azithromycin in the treatment of mycoplasma pneumonia respectively. Methods 116 children patients with mycoplasma pneumonia were randomly divided into group I and group II . Group I was treated with erythromycin by intravenous drip injection 30 mg/（kg, d） and then azithromycin 10 mg/（kg· d） by oral administration during the treatment. Group Ⅱ was treated with azithromycin by intravenous drip injection 10 mg/（kg·d） and then by oral administration with the same dosage. The clinical efficacy and adverse reactions were observed. Results The total efficiency of group Ⅰ and groups Ⅱwere 96.6% and 89.7% respectively and there was no statistical difference between the two groups. The disappearance times of chnical symptoms and signs in group Ⅰ were shorter than that of group Ⅱ（X^2= 78.86, P 〈 0.05 ）. There was no statistical difference between the two groups in adverse reactions during the treatment. Conclusions The sequential treatment of erythromycin and azithromycin was more effective than that of azithromycin and the former was safer and more economic.