脑钠肽和肝硬化心肌病研究进展

Research progress of brain natriuretic peptide and cirrhotic cardiomyopathy

肝硬化心肌病（CCM）是肝硬化并发症之一，近年逐渐受到临床的重视。脑钠肽（BNP）目前已成为心功能不全实验室指标之一，并被视为CCM潜在标志物之一。此文对BNP生物学特性、CCM发病机制以及BNP在CCM中的运用等方面的研究进展作了综述。

Cirrhotic cardiomyopathy （CCM） is one of the complications in liver cirrhosis and is paid more attention in clinical research. The brain natriuretie peptide（BNP）, a neuroendoerine hormones highly sensitive to early cardiac dysfunction, is a strong predictor of heart failure, myocardial injury and cardiac dysfunction. Increased plasma BNP levels in patients with liver cirrhosis are correlated with the severity of liver diseases and can indicate the existence of cirrhotic cardiomyopathy. In this article, the progress about BNP and CCM is reviewed.