配对血浆滤过吸附的技术原理与研究现状

Principle and research status about coupled plagna filtration adsorption

危重病患者往往伴随全身炎症反应综合征、水电解质酸碱失衡及血流动力学不稳定等情况。血液净化技术治疗危重病患者的目标在于纠正这种复杂的内环境紊乱，而联合应用多种血液净化技术更利于这一目标的实现。配对血浆滤过吸附（CPFA）是近年来出现的一种连续性的、且联合应用血浆吸附与血液滤过的新技术。此文综述了CPFA的概念及技术原理，CPFA的体外、动物实验和初步的临床研究结果，并探讨其临床应用前景。

Serious and critical diseases are often accompanied with systemic inflammatory response syndrome, water-electrolyte and acid-base imbalance, hemodynamic instability, and so on. The goal of blood purification treatment on these patients is to correct the complex internal environment disorder, and the combination of different models can benefit on the achievement of that goal. Coupled plasma filtration adsorption （CPFA）, combined plasma adsorption and blood fdtration together, is a novel continuous blood purification technology in recent years. In this article, the concept and principle of CPFA are introduced, preliminary results of CPFA in vitro and animal experiments as well as clinical researches are summarized, prospects for clinical application of CPFA are explored.