摘要
研究了RADA16-I纳米短肽的二级结构和微观形态及其在不同溶液触发下形成的水凝胶的力学强度。试验结果表明,该短肽在水溶液中形成典型的β-sheet结构,这对其形成纳米纤维十分重要。此外,研究发现采用不同的溶液触发得到的水凝胶的力学强度可在一定范围内变化,符合DLVO理论。这可为组织工程提供强度可调控的纳米纤维支架材料。
In this study, secondary structure, micromorphology and rheology properties of peptide RADA16-I are investigated. The peptide forms a typical β-sheet structure, which is significant for nanofiber formation. Moreover, when triggered by different solution, the storage modulus of the hydrogels can vary within certain range and this property is in compliance with DLVO theory. This provides RADA16-I nanofiber scaffolds with controllable mechanical strength for tissue engineering, the major application of peptide materials.
出处
《材料导报》
EI
CAS
CSCD
北大核心
2009年第8期33-35,共3页
Materials Reports
基金
四川大学"985"自然科学基金(0083604127032)
关键词
自组装
短肽
水凝胶
纳米纤维
生物材料
self-assembly, peptide, hydrogel, nanofiber, biomaterial
