177例新疆南部维吾尔族尿结石成份分析与代谢评价

Analysis of chemical composition of urinary stones and evaluation of metabolic disturbance in 177 patients which in Uigurs nationality of south Xingjiang

目的:研究新疆南部维吾尔族结石成分与代谢异常的关系。方法:分析177例泌尿系结石患者的结石成分及完整血生化及24h尿分析结果。结果:草酸钙结石135例(76.3%),感染性结石2例(1.1%),尿酸结石24例(13.6%),磷酸盐结石14例(7.9%),胱氨酸结石2例(1.1%)。24h尿分析结果患者中代谢异常129例(72. 9%),其中高钙尿症40例(22.6%),高尿酸尿症62例(35.0%),高草酸尿症43例(24.3%),高尿磷71例(40. 1%),低枸橼酸尿症117例(66.1%),低尿镁症59例(33.3%),24h尿量<2 000ml者124例(70.1%),高胱氨酸尿症2例(1.1%)。结论:结石与多种代谢异常关系密切;确定结石成分及患者的代谢评价对泌尿系结石的成因、治疗和预防有重要的临床意义。

Objective： To study the relationship between chemical composition of urinary stones and metabolic disturbance in Uigurs nationality of south Xingjiang. Methods ： 177 urinary stone patients who had undergone analysis of stone composition were evaluated of them had entire blood biochemistry results and 24 - h urine analysis results. The relationship between stone composition and metabolic disturbance was analyzed using χ2 test. Results：Calcium oxalate stones were found in 135 cases（76.3% ） ,infection stones in 2 cases （ 1.1% ）, uric stones in 24 cases （ 13.6% ）, phosphate stones in 14 cases （7.9%） and cystine stones in 2 cases （ 1.1% ）. Metabolic disturbance was found in 129（72.9% ） of 177 patients with entire blood biochemistry results and 24 -h urine analysis results. Among the 129 patients, hypercalciuria occurred in 40 cases （ 22.6% ）, hyperuricosuria in 62 cases （ 35.0% ）, hyperoxluria in 43 cases （ 24.3% ）, hyperphophauria in 71 cases （ 40. 1% ）, hypocitraturia in 117 cases （66.1%） ,hypomagnesiuria in 59 cases （33.＇3%） ,24 -h urine volume 〈 2000ml in 124 cases （70.1% ） ,cystinuria in 2 cases （1.1% ）. Conclusions：Urinary stone recurrence is closely related with more than one kinds of metabolic disturbances. Stone composition analysis and metabolic evaluation are very important in finding the causes and in treating and preventing urinary stones.