血、腹水Ⅲ型前胶原肽联合检测在肝脏疾病中的临床价值

The value of combined determination of type Ⅲ procollagen in blood and ascite in patients with hepatic disease

目的:探讨血、腹水Ⅲ型前胶原肽(PⅢP)联合检测在肝脏疾病中的临床价值。方法:采用放射免疫法同步测定50例对照组,25例肝硬化失代偿患者血、腹水中Ⅲ型前胶原肽含量变化。结果:肝硬化患者血、腹水中PⅢP含量均明显高于对照组,差异有统计学意义,腹水中PⅢP含量明显高于血清PⅢP含量,P<0.001;以120μg/L为临界值,计算其95%可信区间内其PⅢP敏感性、特异性、真实性均为腹水>血。结论:肝炎后肝硬化患者无论血、腹水中PⅢP检测均可获得较高的敏感性和特异性。PⅢP含量测定对诊断肝纤维化有一定的价值,其血清含量变化在反映肝硬化、肝细胞坏死及肝功能损害程度方面具有一定的临床实用价值。

Objective： to investigate the value of combined peptide of type m procollagen（PⅢP） concentration assay in blood and ascite in patients with hepatic diseases. Methods： to investigate the PⅢP concentration in blood and ascite from patients with hepatic cirrhosis and control group. Results：the PⅢP content of patients with cirrhosis was higher than that of the control group （P〈0.001） , in cinhosis patients, the PⅢP content in ascite was higher than that in blood. Given 120μg/ml as critical value, the sensitivity, specificity, and accuracy of PⅢP content were higher than those of the control group. Conclusion：the investigation of PllI P concentration is valuable for diagnosis of hepatic fibrosis.