左氧氟沙星对幽门螺杆菌感染补救治疗疗效观察

The study of levofloxacin as rescue therapy for Helicobacter pylori infection

目的探讨左氧氟沙星三联方案对幽门螺杆菌感染进行补救治疗的疗效。方法64例患者经胃镜以及病理检查证实为消化性溃疡,并且经一线治疗方案根除失败,给予雷贝拉唑10mg,左氧氟沙星200mg,阿莫西林1000mg,2次/d,疗程7d。治疗4周后行14C呼气试验。结果64例患者中56例HP阴性,根除率为87.5%,其中仅有2例出现轻度不良反应。结论对HP根除治疗失败的患者左氧氟沙星为安全有效的补救治疗方案。

Objective To evaluate the effect of rescue therapy for eradicating Helicobacter pylori （Hp） with levofloxacin Amoxicilin and Rebeprazole. Methods Sixty-four patients were diagnosed as digestive ulcer throughout gastroscopic examination and histopathogy, and Helicobacter pylori was positive. They were treated by first-line therapy, but failed. In our test groups the patients were treated with levofloxacin 200 mg Amoxicilinl000 mg and Rebeprazole10 mg bid for 7 days. The ^14C-urea breath test （UBT） was performed to evaluate the success of Hp eradication, at least four weeks after completion therapy. Results There were 56 subjects eradicated, the eradication rate was 87.5%. Conclusion Levofloxacin Amoxicilin and Rebeprazole triad system as rescue therapy for Helicobacter pylori is an effective and safe rescue therapy after failed first-line triple therapy.