硫糖铝和黄连素治疗顽固性慢性胃炎疗效观察

Effect observation of berberine and sucralfate in the treatment of chronic gastritis

目的观察硫糖铝、黄连素治疗顽固性慢性胃炎的临床效果。方法以自身对照的方法用硫糖铝、黄连素治疗经常规抗酸和清除幽门螺杆菌(Hp)治疗无效的慢性胃炎152例,2周为1个疗程,1～2个疗程症状及体征明显改善后,减量维持治疗3个月。结果152例顽固性慢性胃炎患者使用硫糖铝、黄连素治疗3个月后,治愈103例,有效40例,无效9例,1年内复发5例,总有效率为94.74%。其中31例Hp阳性慢性胃炎患者,有20例转为阴性,Hp阴转率为64.52%。结论硫糖铝、黄连素治疗慢性胃炎和促进Hp转阴具有安全、有效、不良反应轻微的特点,而且价廉低廉,服用简便,可以作为治疗慢性胃炎的有效方法之一,值得临床推广使用。

Objective To observe the clinical effect of berberine and sucralfate in the treatment of chronic gastritis. Methods Take one＇ s self-contrast method 152 cases of patients with chronic gastritis that was invalid by conventional treatment of suppressing the gastric juice and sterilizing Hp, then were treated with sucralfate and berberine, this is 2 weeks for a course of treatment, when symptoms and physical signs significantly improved in one or two course , reduced dosage and continue to treatment for 3 months. Results After 152 cases of patients with chronic gastritis were treated with sucralfate and berberine in 3 months, 103 cases were cured,40 cases were effective and 9 cases were ineffective, but there were 5 cases to recur in one year,the total effective rates were 94. 74%. Of 31 Hp positive patients,20 case became seronegative, the negative conversion rates of Hp were 64. 52%. Conclusions Berberine and sucralfate to treat the chronic gastritis and prompt the negative conversion of Hp were security, effective and mild side effects, lower cost , taked medicine simply and easily, It should be used as one of the effective ways to cure chronic gastritis, which is worth being spread.