硫糖铝对消化性溃疡涂抹研究

The painting study of sucralfate in Peptic ulcer

目的通过研究硫糖铝对消化性溃疡涂抹情况,以探讨硫糖铝对消化性溃疡保护作用,为临床用药提供理论依据。方法将24例患者随机分为对照组(慢性浅表性胃炎)和胃溃疡组12例,空腹嚼服硫糖铝。其余24例患者随机分为对照组(慢性浅表性胃炎),十二指肠溃疡组,空腹口服硫糖铝悬液。服药30min后进行胃镜检查,观察硫糖铝对上消化道黏膜涂抹情况。结果与对照组比较,胃溃疡组胃窦部涂抹均匀;十二指肠溃疡组十二指肠球部涂抹均匀。结论硫糖铝向溃疡部位聚集,更好的保护病变处黏膜。

Objective To investigate the role of protection of sucralfate and provide a theory basis for clinical medication by studying the effection of painting sucralfate in Peptic ulcer. Methods 24 patients with administration of sucralfate chewable tablet were divided randomly into the control group （ chronic superficial gastritis,CSG） and the gastric ulcer group; the other 24 patients with administration of sucralfate suspension were divided randomly into control group（CSG） and gastric ulcer group. After 30 minutes with administration of sucralfate, the painting of sucralfate in upper gastrointestinal mucous membrane were observed by gastroscope. Results Compared with the control group, the scores of the painting of sucralfate in sinus ventriculi of gastric ulcer group and in duodenal bulb of gastric ulcer group increased（ P = 0. 027, P = 0. 035 ）. Conclusion The ulcer can be better protected by sucralfate aggregated.