MadCAM-1表达与胃癌发生相关性的研究

Immunoreactivity of mucosal addressin cell adhesion molecule-1 and tumorigenesis of human gastric cancer

目的:探讨胃癌发生发展中黏膜地址素细胞黏附分子-1(MadCAM-1)的变化对胃癌的影响。方法:采用免疫组织化学SP法,检测50例行胃癌根治术所收集的癌组织、癌旁组织、正常胃黏膜组织中Mad-CAM-1的表达情况。结果:MadCAM-1表达率在正常胃黏膜、癌旁组织及癌组织中分别为78%(39/50)、64%(32/50)和40%(20/50)。癌组织中的阳性表达率明显低于正常组织(χ2=14.924,P=0.000)和癌旁组织(χ2=5.769,P=0.016);而正常组织与癌旁组织之间差异无统计学意义,P>0.05;MadCAM-1阳性表达率低年龄组(<45岁)表达低于高年龄组(>45岁),χ2=4.688,P=0.030;MadCAM-1的阳性表达率与Borrmarn分型、肿瘤部位、肿瘤大小及癌细胞的浸润深度和分化程度无关,P>0.05。结论:MadCAM-1参与肿瘤局部免疫过程,与胃癌发生发展有关。MadCAM-1的低表达可能使机体局部免疫能力降低导致了胃癌的发生。

OBJECTIVE： To explore the influence of expressions of MadCAM-1 on gastric carcinoma during the process of arising and development of gastric carcinoma. METHODS： By the im munohistochemical method, the expressions of MadCAM-1 were studied in gastric carcinoma, normal gastric tissues and cancer ad jacent tissues of 50 collected specimens when carried out radical re section of gastric carcinoma. RESULTS： The expressions of MadCAM-1 were 78%（39/50）, 64%（32/50） and 40%（20/50） in norma gastric mueosae, cancer-adjacent tissues and gastric carcinoma tissue. respectively. The expression rate of MadCAM-1 was higher in gastric carcinoma tissues than in normal gastric mucosae （χ^2 = 14. 924, P= 0. 000） and cancer-adjacent tissues （χ^2 = 5. 769, P = 0. 016）, anc there was no significant difference between normal gastric mucosae anc cancer-adjacent tissues （P〉0. 05）. The expression rate of MadCAM-1 was lower in the young group（〈45 y） than in the old group（〉45 y） χ^2 =4. 688, P=0. 030. The expression of MadCAM-1 showed no cot relation with the Borrmarn type, tumor location, tumor size and th（ differentiation and infiltration grade of gastric carcinoma, P〉 0. 05. CONCLUSIONS： MadCAM- 1 participates in the local immunity of cancer. The low expression of MadCAM-1 may decrease the immune competence and induce carcinogenesis of gastric carcinoma.