Musclin：一种新的与胰岛素抵抗有关的骨骼肌细胞源性因子

Musclin：a novel skeletal muscle-derived secretory factor related to insulin resistance

肌肉素（musclin）是与利钠肽相似的多肽，其蛋白与利钠肽家族的切割方式不同，因此可能无利钠肽的活性。重组musclin与糖脂代谢有关，其降低了胰岛素诱导的成肌细胞C2C12葡萄糖摄取及糖原合成的能力。由此表明，musclin可能参与骨骼肌胰岛素抵抗（IR）。然而，目前对musclin的研究很少，其参与IR的具体机制尚不清楚，还需进一步研究。

Musclin is a peptide similar to natriuretic peptides （NP）. Different from the NP family, the conserved 17 amino acids of musclin are not positioned between two cysteine residues, which are crucial for physiological protein folding to produce natriuretic activity. Musclin significantly attenuated insulin-stimu- lated 2-DG uptake and glycogen synthesis at both basal and insulin-stimulated status in C2C12 myoblasts. Musclin might be involved in insulin resistance （IR） in skeletal muscle. However,there is little research on the musclin by now, and the specific mechanisms involved in IR is not clear, which need to be further studied.