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病毒样颗粒技术的研究进展 被引量：13

Progress in Virus-Like Particles Technique Studies
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摘要 病毒样颗粒(Virus-like Particles,VLPs)为不含病毒基因组的空壳或包膜状颗粒结构,与天然病毒颗粒结构相似。VLPs技术在病毒的组装与形态多样性等基础研究中发挥了重要作用。VLPs作为疫苗,可有效诱导机体产生免疫反应。VLPs具有独特的免疫学特性,不但能通过影响抗原递呈细胞发挥佐剂效应,还可以作为其它佐剂、多肽疫苗和核酸疫苗的整合平台设计多种形式的疫苗。在适宜条件下,VLPs可以包裹核酸或其它小分子物质,因此可以作为分子运载工具靶向性地递送基因或药物。VLPs还可以替代天然病毒在免疫学检测中发挥重要作用。 Virus-like particles （VLPs） structurally mimic the authentic virus whereas contain no viral genome. VLPs technique plays an important role in basic research such as virus assembly and virus morphology diversity. With special immunology properties, VLPs vaccine can induce immune response effectively. VLPs can act as adjuvant by regulating dendritic cells. Other adjuvant or polypeptide can be integrated into VLPs to construct chimeric vaccines. With the capability of packaging nucleic acid or other small molecules, VLPs can be used for vehicles to deliver these substances under suitable conditions. VLPs can substitute natural virus in immunology assay.
作者 郭建强 张智清
机构地区 中国疾病预防控制中心病毒病预防控制所病毒基因工程国家重点实验室
出处 《中国疫苗和免疫》 CAS 2009年第2期167-173,共7页 Chinese Journal of Vaccines and Immunization
关键词 病毒样颗粒 疫苗 载体 免疫学检测 Virus-like particles Vaccine Vehicle Immunology assay
分类号 R373 [医药卫生—病原生物学]
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参考文献47

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中国疫苗和免疫
2009年 第2期

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