法莫替丁与奥美拉唑治疗儿童消化道出血105例对照分析

Clinical comparison of Famotidine and Omeprazole in the treatment of children gastrointestinal bleeding

目的:观察法莫替丁治疗儿童消化道出血的临床疗效与安全性。方法:将105例儿童消化道出血患者随机分为3组。治疗A组39例,采用法莫替丁每次0.9mg/kg;治疗B组35例,每次给法莫替丁0.5mg/kg;对照组31例,每次给奥美拉唑0.9mg/kg。3组给药均12h1次,疗程1周。结果:治疗A组、治疗B组、对照组的总有效率分别为94.87%、77.14%、96.77%,治疗A组与对照组疗效相当(P>0.05),明显优于治疗B组(P<0.05);3组均未见临床不良反应。结论:法莫替丁治疗儿童消化道出血采用每次0.9mg/kg、12h1次的治疗方案,其疗效与奥美拉唑相当,安全性较好。

Objective： The clinical effects and safety of Famotidine in the treatment of children gastrointestinal bleeding. Methods： 105 cases of children gastrointestinal bleeding were divided into three groups. There were 39 patients in control group A, which were treated with Famotidine 0.9mg per kg per time. 35 patients were in control group B which were treated with Famotidine 0. 5mg per kg per time. 31 patients were in comparison group, which were treated with Omeprazole 0. 9mg per kg per time. Results： The total efficiency of control group A, control group B, and comparison group were 94. 87%, 77. 14%, 96. 77% respectively. The effect of control group A was equivalent with the control group B （P〉0.05）, and distinctly excel the group B （P〈0. 05）. There were no bad symptoms in three groups. Conclusion：The effect of the Famotidine 0.9mg per kg per time has the same effect with Omeprazole, and the safety is good.