膀胱尿路上皮细胞癌MUC1和MUC2蛋白的表达及临床意义

Expression and Significance of MUC1and MUC2 in Transitional Cell Carcinoma of Bladder

目的:探讨粘蛋白(MUC1)和MUC2蛋白在膀胱尿路上皮细胞癌中的表达及其与临床病理的相关性。方法:应用免疫组织化学技术检测60例膀胱尿路上皮细胞癌和8例正常膀胱粘膜MUC1和MUC2蛋白的表达。结果:MUC1在正常膀胱粘膜及膀胱尿路上皮细胞癌中都有不同程度的表达,60例膀胱尿路上皮细胞癌标本中阳性表达50例(83.3%),阳性表达率与肿瘤的病理分级、TNM分期显著相关。MUC2在正常膀胱粘膜无表达,60例膀胱尿路上皮细胞癌中阳性表达27例(45.0%),且在不同病理分级,TNM分期之间表达均无显著性差异。结论:膀胱尿路上皮细胞癌组织中MUC1和MUC2联合检测可作为判断膀胱尿路上皮细胞癌分级、分期的一个参考指标。

Objective：To investigate the expression of MUC1 and MUC2 proteins and their significance in human bladder transitional cell carcinoma（BTCC）. Methods： Immunohistochemistry was used to detect the expression of MUC1 and MUC2 proteins in 60 cases of BTCC and 8 subjects of normal bladder mucosa. Results： MUC1 had different level of expression in both normal bladder mucosa and BTCC.The positive expression of MUC1 in BTCC was 50 cases（83.3%）.Positive rate and expression patterns were correlated with high pathological grades and TNM stages.MUC2 was negative in all normal bladder mucosa. The positive expression in BTCC was 27 cases（45.0%）.There was no significant different expression of MUC2 with the pathological grades and different TNM stages.Conclusion： There is a relationship between the expression of MUC1 and MUC2 in BTCC, combining detection could be useful indicator for the assessment of pathological grades or TNM stages of BTCC.