p53野生型与突变型上皮性卵巢癌临床病理特征比较

Comparison of p53 Wild-type and Mutated Clinicopathological Characteristics in Epithelial Ovarian Cancer

目的:探讨p53基因野生型和突变型上皮性卵巢癌的临床病理特征差异。方法:收集经手术病理证实的上皮性卵巢癌病例105例,按免疫组化方法检测癌组织中p53蛋白表达将其分为p53野生型组和突变型组,比较两组发病年龄、病理分期、组织学分类和分化程度等特征。结果:p53野生型组和突变型组卵巢肿块平均长径分别为13.2±7.8cm与8.5±5.4cm,前者显著大于后者(P<0.01)。p53野生型组I期患者占60.0%,p53突变型组晚期患者占64.3%。野生型组卵巢浆液性癌、内膜样癌、透明细胞癌的比例相似,都在25%左右;而p53突变型组高达67.1%的病理类型为浆液性癌。两组患者的肿瘤分期和病理类型构成比有显著性差异。两组患者年龄、肿瘤累及双侧的比率以及组织学分级均无统计学显著差异。结论:p53基因的突变与上皮性卵巢癌的发生密切相关,但是它在不同病理类型的上皮性卵巢癌的发生中所起的作用是不同的。

Objective：To explore the difference of clinical and pathological characteristics between wild-type and mutated p53 in epithelial ovarian cancer. Methods：The data of patients of epithelial ovarian cancer with operative and histologically-confirmed were colected. According the expression of p53 protein in epithelial ovarian cancer tissue detected using immunohistochemistry, patients were divided into wild-type group and mutated group.Results：The mean size of ovarian tumour in p53 wild-type group and mutated group was 13.2±7.8 cm and 8.5±5.4 cm, respectively.The former was bigger significantly than the latter （P〈 0.01 ）. 60% patients in p53 wild-type group were Stage Ⅰ, while 64.3% patients in p53 mutated group were advanced stage. In p53 wild-type group, the proportion of ovarian serous cancer, endometrioid cancer and clear cell cancer was similar, but 67.1% pathological type in mutated group was serous cancer （P〈0.05）. Age of patients, unilateral or bilateral tumour and histological grading showed no statistical difference. Conclusion：Mutation in anti-oncogenen p53 might play a significant role in pathogenesis and development in epithelial ovarian Cancer, but its role was difference between different pathological type ovarian cancer.