血管硒蛋白与动脉粥样硬化

Vascular Selenoproteins and Atherosclerosis

动脉粥样硬化是一种严重危害人类健康的慢性炎症血管疾病,随着我国人民生活水平的不断提高和人口的老龄化,其发病率逐年增高。本文结合本课题组的工作,对血管硒蛋白与动脉粥样硬化的关系进行了介绍。主要的研究进展表明:动脉粥样硬化的发生与血管氧化性损伤有密切关系,硒作为一种重要的必需微量元素主要以硒蛋白的形式存在于血管之中,对氧化型固醇导致的血管损伤有明显地抑制作用;其机理可能与硒蛋白的抗氧化作用、调节血液前列环素和血栓素的比例改善血液流通、以及抑制氧化型固醇诱导的血管细胞凋亡等有关。

Atherosclerosis, a chronic inflammatory disease of the arterial wall, exerts serious influence to human health. Along with the rising living standard and aging of the population, the morbidity of atherosclerosis increases year by year. This review discusses the relationship between vascular selenoprotein and atherosclerosis in corporation with authors＇ work. Recent progresses show that the occurrence and development of atherosclerosis are closely related to oxidative damage of blood vessels, and selenium, as an essential trace element for humans, exerts its biological effect through selenoproteins and plays an important role in the inhibition of vascular oxidative damage and the prevention atherosclerosis induced by oxysterols. The mechanism may be related to （i） effect on antioxidant capacity of arterial wall, （ii） regulation of oxysterols-induced abnormal ratio of prostacyclin and thromboxane, （iii） inhibiting effect on oxysterolsinduced apoptosis of vascular smooth muscle cells.