摘要
为了研究中药地锦草抗HBV的活性物质基础,采用大孔树脂、Sephadex LH-20、MCI GEL CHP 20P等色谱方法,从地锦草70%乙醇提取物中分离得到5个芹菜素苷类化合物,通过MS、NMR、2D-NMR等波谱分析手段鉴定了化合物的结构,分别为:芹菜素-7-O-(6"-O-没食子酰)-β-D-葡萄糖苷(1),芹菜素-7-O-β-D-芹糖(1→2)-β-D-葡萄糖苷(2),芹菜素-7-O-β-D-芦丁糖苷(3),芹菜素-7-O-β-D-葡萄糖苷(4),芹菜素(5)。化合物1为新化合物,化合物2、3为首次从该植物中分得。
The investigation on the herbal of Euphorbia humifusa Wild. was carried out in order to find its anti-HBV constituents. The isolation and purification were performed by chromatography such as Sephadex LH-20, MCI GEL CHP 20P, etc. Based on the spectral analysis, five apigenin glycosides were identified as apigenin-7-O-( 6″-O-galloyl)-β-D-glucopyranoside (1), apigenin-7-O-β-D-apiofuranosyl (1→2)-β-D-glucopyranoside (2), apigenin-7-O-β-D-lutinoside (3), apigenin-7-O-β-D-glucopyranside (4) and apigenin (5). Among them, compound 1 is a new compound, compound 2 and 3 were isolated from this plant for the first time.
出处
《药学学报》
CAS
CSCD
北大核心
2009年第5期496-499,共4页
Acta Pharmaceutica Sinica
基金
国家自然科学基金资助项目(30600803)
关键词
地锦草
芹菜素糖苷
衍生物
Euphorbia humifusa Wild.
apigenin glycoside
derivatives